安徽医科大学学报2026，Vol.61Issue(7)：1325-1332,8.DOI:10.19405/j.cnki.issn1000-1492.2026.07.023
乳酸代谢重编程靶向治疗在类风湿性关节炎中的免疫作用
Immune role of targeting lactate metabolism reprogramming in rheumatoid arthritis
摘要
Abstract
Rheumatoid arthritis(RA)is a chronic autoimmune disease characterized by persistent synovial inflam-mation and progressive joint destruction.Recent studies have shown that lactate metabolic reprogramming plays a key role in the pathological process of RA,and the accumulation of lactate in the synovial microenvironment trig-gers a cascade of immune regulatory effects.These metabolic changes create a self-sustaining cycle of inflammation and tissue damage,leading to progressively worsening disease.Therefore,lactate metabolism has been identified as a therapeutic target.Therapeutic strategies targeting lactate metabolism,such as LDHA inhibitors,targeting PKM2,MCT inhibitors,GPR81 antagonists,lactylation modification regulators,and nanosponges,have shown great potential in restoring immune balance and protecting joint integrity.This review summarizes the mechanisms of lactate metabolism in RA and its therapeutic applications,providing a theoretical basis for the development of novel metabolic intervention therapies.关键词
乳酸代谢/类风湿关节炎/免疫失衡/乳酰化修饰/代谢重编程/免疫作用/靶向治疗Key words
lactic acid metabolism/rheumatoid arthritis/immune imbalance/lactylation modification/meta-bolic reprogramming/immune function/targeted therapy分类
医药卫生引用本文复制引用
童家烨,郑美娟..乳酸代谢重编程靶向治疗在类风湿性关节炎中的免疫作用[J].安徽医科大学学报,2026,61(7):1325-1332,8.基金项目
国家自然科学基金项目(编号:92269109) National Natural Science Foundation of China(No.92269109) （编号:92269109）
