滨州医学院学报2026，Vol.49Issue(4)：400-406,7.DOI:10.19739/j.cnki.issn1001-9510.2026.04.012
葛根素多孔淀粉微球的制备、表征及其提高口服生物利用度的途径
Preparation,characterization and oral bioavailability enhancement of puerarin-loaded porous starch microspheres
摘要
Abstract
Objective To construct puerarin-loaded porous starch microspheres(PS@PUE),characterize their pharmaceuti-cal properties,investigate the feasibility and underlying mechanism for improving the oral bioavailability(BA)of puerarin(PUE),in order to provide support for the development of novel oral formulations of puerarin.Methods PS@PUE were pre-pared via a solvent adsorption method.Scanning electron microscopy was employed to observe the morphological characteristics of the microspheres,and high-performance liquid chromatography was used to determine the drug loading properties.In vivo phar-macokinetic experiments in rats were conducted to evaluate the efficacy of the microspheres in enhancing the oral BA of PUE.The mechanism by which PS@PUE improved oral absorption was elucidated using differential scanning calorimetry,X-ray diffraction,and in vitro release experiments.Results The prepared PS@PUE exhibited a drug loading capacity of 14.89%and an encapsu-lation efficiency of 71.28%.SEM results showed that PS@PUE possessed a well-defined spherical structure.Pharmacokinetic results indicated that PS@PUE significantly increased the plasma concentration and BA of PUE.The peak plasma concentration and the area under the concentration-time curve of PS@PUE were 2.4-fold and 2.0-fold higher than those of the control group,respectively.Differential scanning calorimetry and X-ray diffraction analyses revealed that the reduced crystallinity of PUE in the microspheres led to an increase in drug solubility and dissolution rate,which was identified as a critical factor contributing to the improved oral BA of PUE by PS@PUE.Conclusion In this study,PS@PUE with favorable drug-loading capacity were success-fully prepared.They can effectively enhance the oral BA of PUE and exhibit great application potential in the development of no-vel non-injectable preparations of PUE.关键词
葛根素/多孔淀粉微球/生物利用度Key words
puerarin/porous starch microsphere/bioavailability分类
医药卫生引用本文复制引用
刘雪,徐欣雨,王星荟,张琦,钟函静,田宝成..葛根素多孔淀粉微球的制备、表征及其提高口服生物利用度的途径[J].滨州医学院学报,2026,49(4):400-406,7.基金项目
国家自然科学基金(81703717) （81703717）
