滨州医学院学报2026，Vol.49Issue(4)：427-431,5.DOI:10.19739/j.cnki.issn1001-9510.2026.04.017
蛋白质组学技术在冠心病研究中的应用进展
Application advances of proteomics technologies in coronary heart disease research
张奇 1刘茜 1王文龙 1王新宇 1王东1
作者信息
- 1. 山东医药大学附属医院心血管内科 山东 滨州 256603
- 折叠
摘要
Abstract
Proteomics provides a powerful tool for revealing the molecular mechanisms of coronary atherosclerosis through the systematic analysis of protein expression,modifications,and functional networks.This review summarizes the latest advances in proteomics research on coronary heart disease(CHD),with a focus on its contributions to elucidating the mechanisms of plaque formation and rupture,discovering biomarkers for early diagnosis and prognosis prediction,and identifying potential therapeutic targets.It also discusses current technical challenges and looks ahead to future directions,including spatial proteomics,post-translational modification analysis,artificial intelligence-assisted approaches,and multi-omics integration.Proteomics holds promise for advancing the diagnosis and treatment of CHD toward earlier and more precise strategies,thereby improving patient outcomes.关键词
蛋白质组学/冠状动脉粥样硬化性心脏病/生物标志物/动脉粥样硬化斑块/诊断与预后Key words
proteomics/coronary atherosclerotic heart disease/biomarker/atherosclerotic plaque/diagnosis and prognosis分类
医药卫生引用本文复制引用
张奇,刘茜,王文龙,王新宇,王东..蛋白质组学技术在冠心病研究中的应用进展[J].滨州医学院学报,2026,49(4):427-431,5.
