磁共振成像2026，Vol.17Issue(8)：33-41,106,10.DOI:10.12015/issn.1674-8034.2026.08.002
基于区域CBF形态相似性的卵圆孔未闭脑血流网络拓扑特征及其与认知功能的关系
Topological characteristics of cerebral blood flow networks based on regional CBF morphological similarity in patent foramen ovale and their associations with cognitive function
摘要
Abstract
Objective:To construct a cerebral blood flow(CBF)functional network based on arterial spin labeling(ASL)and to investigate alterations in network topological properties in patients with patent foramen ovale(PFO)and their associations with cognitive function.Materials and Methods:A total of 52 patients with PFO and 48 age-and sex-matched healthy controls were prospectively enrolled.CBF was quantified using ASL.The cerebral cortex was parcellated into 200 regions of interest according to the Schaefer atlas.The probability distribution of CBF in each region was estimated using kernel density estimation,and Jensen-Shannon divergence(JSD)was applied to quantify distributional similarity and construct the CBF functional network.Global and nodal topological properties,including global efficiency,clustering coefficient,degree centrality,and nodal efficiency,were calculated.Between-group differences were assessed using independent-samples t-tests.Partial correlation analyses controlling for age,sex,and years of education were further performed to investigate the relationships between abnormal network topological properties and cognitive function.Specifically,we examined correlations with Montreal Cognitive Assessment(MoCA)and Mini-Mental State Examination(MMSE)scores,as well as with PFO anatomical parameters and right-to-left shunt(RLS)grades.Results:(1)Global properties:Compared with healthy controls,patients with PFO showed a statistically significant difference in global efficiency at the uncorrected level(P＜0.05),but the difference was not statistically significant after Bonferroni correction.(2)Nodal properties:Compared with the HC group,patients with PFO exhibited significant nodal topological alterations across multiple functional networks.In the default mode network(DMN),the degree centrality(Dc)and nodal efficiency(Ne)of the left precuneus were significantly decreased,while the Ne and nodal local efficiency(NLe)of the left dorsal prefrontal cortex were reduced.The left posterior cingulate cortex showed decreased Dc and Ne,with increased nodal clustering coefficient(NCp)and NLe.In the right posterior cingulate cortex,betweenness centrality(Bc),Dc,and Ne were decreased,while nodal shortest path length(NLp)was increased.In the fronto-parietal control network(FPN),the right dorsolateral prefrontal cortex showed decreased Bc,Dc,and Ne,whereas NCp and NLe were increased.In the somatomotor network(SMN),the left somatomotor area showed increased Bc,Dc,and Ne,along with decreased NLp.The right somatomotor area demonstrated increased Bc,Dc,and Ne,whereas the right secondary somatosensory cortex showed decreased Bc,Dc,and Ne.In the ventral attention network(VAN),the right inferior parietal lobule exhibited decreased Ne,accompanied by increased NLe and NLp(FDR corrected P＜0.05).(3)Correlation analysis:In the right posterior cingulate cortex,Bc and Dc were positively correlated with MoCA scores,while Ne and Dc were positively correlated with MMSE scores.In the left precuneus,Ne was positively correlated with MoCA scores.In the left posterior cingulate cortex,Dc,NCp,and NLe were positively correlated with MoCA scores,while Ne,Dc,NCp,and NLe were positively correlated with MMSE scores(FDR corrected P＜0.05).Conclusions:Patients with PFO exhibit significant topological reorganization at the nodal level of the CBF network,primarily involving key functional networks such as the default mode network,fronto-parietal control network,and somatomotor network,and these alterations are correlated with cognitive scores.These findings may reveal potential neural mechanisms underlying PFO-related cognitive changes,provide preliminary insights into the relationship between nodal-level network topological changes and cognitive function,and offer an additional neuroimaging perspective for the assessment of cognitive function in patients with PFO.关键词
卵圆孔未闭/磁共振成像/脑网络/脑血流量/动脉自旋标记/图论分析/认知功能Key words
patent foramen ovale/magnetic resonance imaging/brain network/cerebral blood flow/arterial spin labeling/graph theory analysis/cognitive function分类
医药卫生引用本文复制引用
杨丹,梁燕妮,岳松虹,张宁,马晓阳,王俊,李世兰,刘光耀,张静..基于区域CBF形态相似性的卵圆孔未闭脑血流网络拓扑特征及其与认知功能的关系[J].磁共振成像,2026,17(8):33-41,106,10.基金项目
Gansu Provincial Science and Technology Program(No.24YFFA047) （No.24YFFA047）
Lanzhou Science and Technology Bureau Science and Technology Program(No.2023-2-1). 甘肃省科技计划项目(编号:24YFFA047) （No.2023-2-1）
兰州市科技局科技计划项目(编号:2023-2-1) （编号:2023-2-1）
