磁共振成像2026，Vol.17Issue(8)：42-47,63,7.DOI:10.12015/issn.1674-8034.2026.08.003
基于rs-fMRI与频谱动态因果模型的青年人阈下抑郁大脑有效连接特征研究
Study on effective connectivity characteristics of brain in youth with subthreshold depression based on rs-fMRI and spectral dynamic causal modeling
摘要
Abstract
Objective:To investigate the characteristics of effective connectivity in youth with subthreshold depression(SD)and reveal its early neuropathological mechanism based on resting-state functional magnetic resonance imaging(rs-fMRI)and spectral dynamic causal modeling(spDCM).Materials and Methods:Fifty-two participants with SD(SD group)and 51 healthy controls(HC group)aged 15-24 years were enrolled.After preprocessing all rs-fMRI data,we selected the left dorsolateral prefrontal cortex(1DLPFC),right dorsolateral prefrontal cortex(rDLPFC),medial prefrontal cortex(mPFC),and posterior cingulate cortex(PCC)as regions of interest.Effective connectivity(EC)differences were analyzed using spDCM and parametric empirical Bayes(PEB).Correlation analyses were performed between interregional effective connectivity values and clinical scale scores in the SD group.Results:In both groups,bilateral DLPFC exerted inhibitory connectivity toward mPFC and PCC(EC range:-0.435 to-0.200,Pp＞0.95).The mPFC exhibited excitatory connectivity to rDLPFC(EC=0.075,Pp＞0.95),and bidirectional excitatory connectivity was observed between 1DLPFC and rDLPFC(EC range:0.206 to 0.256,Pp＞0.95).Compared with the HC group,the SD group exhibited decreased inhibitory effective connectivity from rDLPFC to mPFC(EC=0.118,Pp＞0.95).No significant correlations were observed between interregional connectivity strengths in the SD group and scores of the 24-item Hamilton Depression Rating Scale(HAMD-24)as well as the Self-Rating Depression Scale(SDS)(r range:-0.215 to 0.254,all P＞0.05).Conclusions:Youth with SD exhibit reduced inhibitory effective connectivity from rDLPFC to mPFC,suggesting that reduced inhibitory control of mPFC by rDLPFC is a concomitant neuroimaging feature of early SD,which can be used as an imaging reference to reflect brain functional alterations in SD.关键词
青年人/阈下抑郁/磁共振成像/静息态功能磁共振成像/频谱动态因果模型Key words
youth/subthreshold depression/magnetic resonance imaging/resting state functional magnetic resonance imaging/spectral dynamic causal modeling分类
医药卫生引用本文复制引用
刘同辉,张帆,李国强,冯伟,李朋,张华文..基于rs-fMRI与频谱动态因果模型的青年人阈下抑郁大脑有效连接特征研究[J].磁共振成像,2026,17(8):42-47,63,7.基金项目
Xianyang Key Research and Development Program(No.L2024-ZDYF-ZDYF-SF-004). 咸阳市重点研发计划项目(编号:L2024-ZDYF-ZDYF-SF-004) （No.L2024-ZDYF-ZDYF-SF-004）
