磁共振成像2026，Vol.17Issue(8)：161-167,7.DOI:10.12015/issn.1674-8034.2026.08.018
酰胺质子转移成像在脑转移瘤诊断与疗效评估中的研究进展
Research progress of amide proton transfer imaging in the diagnosis and efficacy evaluation of brain metastases
摘要
Abstract
Brain metastases(BMs)are common malignant tumors of the central nervous system and severely affect patients' prognosis and quality of life.Therefore,accurate diagnosis and treatment response assessment of BMs are of great significance for clinical management.Amide proton transfer(APT)imaging,as a branch of chemical exchange saturation transfer(CEST)technology,can noninvasively detect intratumoral protein concentration and changes in the metabolic microenvironment,and has shown some potential in studies related to the diagnosis and treatment of central nervous system tumors in recent years.However,current studies on APT imaging in BMs still have several limitations,including relatively small sample sizes,inconsistent scanning parameters and post-processing workflows,differences in APT quantitative metrics and region-of-interest selection,and scattered evidence regarding pathology-related assessment and post-treatment efficacy assessment,and there is a relative lack of systematic reviews specifically focused on BMs.Accordingly,this article reviews the application progress of APT imaging in the differential diagnosis,pathology-related assessment,and post-treatment efficacy assessment of BMs,and discusses its clinical value and future development directions.This review aims to summarize the key evidence and existing challenges of APT imaging in the evaluation of BMs,demonstrate its potential value in improving diagnostic accuracy and post-treatment monitoring of BMs,and provide a reference for future study design and clinical translation.关键词
磁共振成像/酰胺质子转移成像/脑转移瘤/化学交换饱和转移成像/诊断Key words
magnetic resonance imaging/amide proton transfer imaging/brain metastases/chemical exchange saturation transfer imaging/diagnosis分类
医药卫生引用本文复制引用
李玉宁,伍东洋,买丽,李孝忠..酰胺质子转移成像在脑转移瘤诊断与疗效评估中的研究进展[J].磁共振成像,2026,17(8):161-167,7.基金项目
Science and Technology Program Project of Chengguan District,Lanzhou(No.2020-2-11-14) （No.2020-2-11-14）
General In-Hospital Project of the Affiliated Hospital of Gansu University of Chinese Medicine(No.gzfy-2023-04). 兰州城关区科技计划项目(编号:2020-2-11-14) （No.gzfy-2023-04）
甘肃中医药大学附属医院院内一般项目(编号:gzfy-2023-04) （编号:gzfy-2023-04）
