福建农业科技2026，Vol.57Issue(7)：26-32,7.DOI:10.13651/j.cnki.fjnykj.2026.07.004
喂食蛋黄油对DSS诱导小鼠急性溃疡性结肠炎的干预效果
Intervention Effect of Egg Yolk Oil Feeding on DSS-Induced Acute Ulcerative Colitis in Mice
摘要
Abstract
In order to explore the improvement effect of egg yolk oil on dextran sulfate sodium(DSS)-induced acute ulcerative colitis(UC)in mice,ICR mice were used as the model and randomly divided into normal control group,DSS model group,egg yolk oil low-dose group(2.5 mL·kg-1),and high-dose group(5.0 mL·kg-1).The mice were fed with egg yolk oil for 35 days followed by 7 days of DSS induction for UC.The body weight,disease activity index(DAI),colon length,organ index,serum levels of inflammatory cytokines(TNF-α,IL-6,IL-1β,IL-10)and total bile acids(TBA)were measured,and the histopathological changes of colon were observed.The results showed that compared with the DSS model group,the egg yolk oil-fed groups exhibited attenuated body weight loss of mice,reduced the DAI scores(P＜0.05),increased the colon length(P＜0.05),and decreased the swelling indices of cecum,spleen,and liver(P＜0.05).The serum levels of pro-inflammatory cytokines TNF-α,IL-6,and IL-1β were decreased(P＜0.05),while the level of anti-inflammatory cytokine IL-10 was increased(P＜0.05);the serum TBA content was also decreased(P＜0.05).The pathological damage of colon was significantly improved.The group with high dose of egg yolk oil showed better effects than the low-dose group.In conclusion,egg yolk oil exerted ameliorative effects on DSS-induced acute UC in mice,and the underlying mechanism may involve the regulation of inflammatory cytokine balance,improvement of bile acid metabolism,and repair of intestinal barrier function.These findings suggested a promising application prospect for egg yolk oil in the development of high-quality functional foods.关键词
蛋黄油/溃疡性结肠炎/DSS/炎症因子Key words
Egg yolk oil/Ulcerative colitis/DSS/Inflammatory cytokines分类
轻工纺织引用本文复制引用
耿鹏飞,王佑婷,周钊行,钱跃威,刘丽萍,阚启鑫,宋明月..喂食蛋黄油对DSS诱导小鼠急性溃疡性结肠炎的干预效果[J].福建农业科技,2026,57(7):26-32,7.基金项目
广东省功能食品活性物重点实验室项目(2023B1212060058). （2023B1212060058）
