感染、炎症、修复2026，Vol.27Issue(4)：351-356,6.DOI:10.3969/j.issn.1672-8521.2026.04.003
双歧杆菌联合生长抑素、乌司他丁对急性胰腺炎的治疗效果及抗炎机制
Therapeutic efficacy and anti-inflammatory mechanism of Bifidobacterium combined with somatostatin and ulinastatin in acute pancreatitis
崔罗天 1张海洋 1冯延冰 1郑学典1
作者信息
- 1. 南阳市中心医院急诊创伤外科,河南 南阳 473000
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy of adding Bifidobacterium to conventional treatment with somatostatin combined with ulinastatin in patients with acute pancreatitis,and to analyze its influence on the Toll-like receptor 4(TLR4)/nuclear factor-κB(NF-κB)signaling pathway in peripheral blood mononuclear cells.Methods A total of 86 patients with acute pancreatitis admitted to Nanyang Central Hospital from June 2024 to June 2025 were prospectively enrolled and randomly divided into a control group(n=43)and an observation group(n=43)using a random number table method.The control group received somatostatin combined with ulinastatin,while the observation group received additional Bifidobacterium treatment on the basis of the control group.Clinical efficacy,changes in inflammatory markers[C-reactive protein(CRP),interleukin-6(IL-6)],protein expression levels of TLR4 and NF-κB in peripheral blood mononuclear cells,and the incidence of adverse reactions were compared between the two groups.Results The overall response rate in the observation group(95.35%)was higher than that in the control group(76.74%;χ2=4.745,P<0.05).After 7 days of treatment,the modified Marshall score in the observation group was significantly lower than that in the control group(P<0.001).After 7 days of treatment,the levels of CRP,IL-6,protein expression of TLR4 and NF-κB in peripheral blood mononuclear cells,and serum endotoxin levels in peripheral blood in the observation group were significantly lower than those in the control group(P<0.001).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The combination of Bifidobacterium with somatostatin and ulinastatin demonstrates definite efficacy in the treatment of acute pancreatitis,effectively alleviating clinical symptoms and reducing inflammatory responses.The mechanism may be related to the inhibition of TLR4/NF-κB signaling pathway activation in peripheral blood mononuclear cells,with a favorable safety profile.关键词
急性胰腺炎/双歧杆菌/生长抑素/乌司他丁/TLR4/NF-κB信号通路Key words
acute pancreatitis/Bifidobacterium/somatostatin/ulinastatin/TLR4/NF-κB signaling pathway引用本文复制引用
崔罗天,张海洋,冯延冰,郑学典..双歧杆菌联合生长抑素、乌司他丁对急性胰腺炎的治疗效果及抗炎机制[J].感染、炎症、修复,2026,27(4):351-356,6.
