感染、炎症、修复2026，Vol.27Issue(4)：390-395,6.DOI:10.3969/j.issn.1672-8521.2026.04.010
淋巴细胞与血小板乘积对食管胃静脉曲张内镜治疗后再出血风险的评估价值
Value of the lymphocyte-to-platelet product in assessing the risk of rebleeding after endoscopic treatment of gastroesophageal varices
摘要
Abstract
Objective To explore the value of the product of lymphocyte(LYM)and platelet(PLT),designated as LYM×PLT,in assessing the risk of rebleeding after endoscopic treatment of gastroesophageal varices(GOV).Methods A retrospective analysis was conducted on 117 patients with GOV who underwent endoscopic treatment at Luohe Hospital of Traditional Chinese Medicine in Henan Province from January 2023 to January 2025.According to postoperative rebleeding status,patients were divided into a rebleeding group(36 cases)and a non-rebleeding group(81 cases).Baseline data,preoperative liver function,immunological and coagulation indicators,and internal diameter of the main portal vein were compared between the two groups.Multivariate logistic regression analysis was used to identify factors influencing the risk of rebleeding after endoscopic treatment in patients with GOV.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of LYM×PLT for rebleeding risk after endoscopic treatment in GOV patients.Results The proportion of patients with severe variceal grade in the rebleeding group was significantly higher than that in the non-rebleeding group(P<0.05).Levels of albumin,LYM,PLT,and LYM×PLT in the rebleeding group were lower than those in the non-rebleeding group,while total bilirubin,international normalized ratio,proportion of Child-Pugh class C,and internal diameter of the main portal vein were higher than those in the non-rebleeding group(P<0.05).Multivariate logistic regression analysis showed that decreased LYM×PLT,Child-Pugh class C,and increased internal diameter of the main portal vein were independent risk factors for rebleeding after endoscopic treatment in patients with GOV(OR=0.964,95%CI:0.939-0.989,P=0.005;OR=3.228,95%CI:1.454-7.169,P=0.004;OR=1.298,95%CI:1.008-1.672,P=0.044).ROC curve analysis demonstrated that the area under the curve of LYM×PLT for predicting rebleeding risk after endoscopic treatment in GOV patients was 0.884,with a cutoff value of 149.51×109/L2,a Youden index of 0.679,and a sensitivity and specificity were 88.89%and 79.01%,respectively.Conclusions Decreased LYM×PLT is an independent risk factor of rebleeding after endoscopic treatment of GOV and demonstrates good predictive value,providing a reference for identifying high-risk patients and optimizing management strategies.关键词
食管胃静脉曲张/再出血/内镜治疗/淋巴细胞与血小板乘积/风险评估Key words
gastroesophageal varices/rebleeding/endoscopic treatment/lymphocyte-platelet product/risk evaluation引用本文复制引用
段锐,杨凯歌,侯曦,申晓稚..淋巴细胞与血小板乘积对食管胃静脉曲张内镜治疗后再出血风险的评估价值[J].感染、炎症、修复,2026,27(4):390-395,6.基金项目
2022年度河南省中医药科学研究专项课题(2022ZY1194) （2022ZY1194）
