感染、炎症、修复2026，Vol.27Issue(4)：416-421,6.DOI:10.3969/j.issn.1672-8521.2026.04.015
Treg与MDSC在脓毒症相关急性肺损伤中的作用及转化前景
Role and translational prospects of Treg and MDSC in sepsis-associated acute lung injury
摘要
Abstract
Sepsis-associated acute lung injury(SALI),as one of the most common complications of sepsis,is a major cause of death in critically ill patients.Its core pathological mechanism involves a fatal immune imbalance that transitions from an early hyperinflammatory response to late-stage immunosuppression.While traditional perspectives have focused on hyperinflammation,the role of immunosuppression in the development and progression of sepsis-associated ALI has become increasingly prominent in recent years.Regulatory T cells(Tregs)and myeloid-derived suppressor cells(MDSCs),as key immune regulatory hubs,play dual roles in the progression of sepsis and lung injury,profoundly influencing the occurrence,development,and outcome of SALI.This review systematically synthesizes the existing literature to clarify the respective and interrelated roles of Tregs and MDSCs in the pathogenesis of SALI.At the same time,based on the latest research progress,itlooks forward to the translational prospects of both as potential therapeutic targets for SALI,with the aim of providing theoretical basis and research directions for future immune regulation therapy.关键词
调节性T细胞/髓源性抑制细胞/脓毒症/急性肺损伤/免疫代谢/转化医学Key words
regulatory T cell/myeloid-derived suppressor cell/sepsis/acute lung injury/immunometabolism/translational medicine引用本文复制引用
李锦如,陈志霞,刘志恒,李泉..Treg与MDSC在脓毒症相关急性肺损伤中的作用及转化前景[J].感染、炎症、修复,2026,27(4):416-421,6.基金项目
广东省自然科学基金面上项目(2025A1515011341) （2025A1515011341）
深圳市"医疗卫生三名工程"项目(SZSM202311003) （SZSM202311003）
