感染、炎症、修复2026，Vol.27Issue(4)：422-426,5.DOI:10.3969/j.issn.1672-8521.2026.04.016
肿瘤手术麻醉:围手术期免疫微环境调控与术后复发预防
Tumor surgery anesthesia:Perioperative modulation of the immune microenvironment and prevention of postoperative recurrence
摘要
Abstract
Radical tumor resection remains a critical component of curative treatment for most patients with solid tumors.However,surgical trauma,neuroendocrine stress,inflammatory response,and immune cell function remodeling may create a highly dynamic host environment during the early postoperative period,thereby affecting circulating tumor cells,minimal residual disease,and premetastatic niches.In recent years,whether anesthesia and analgesia strategies influence tumor recurrence by modulating the perioperative immune microenvironment has become an important question in onco-anesthesiology.Current clinical evidence does not support simply designating any specific anesthetic technique as inherently"anti-tumor";rather,the negative findings suggest that perioperative oncological outcomes are shaped by a complex interplay of tumor type,baseline immune status,magnitude of surgical injury,standardization of interventions,postoperative complications,and adjuvant therapies.Myeloid immune cells,especially tumor-associated macrophages,neutrophils,and myeloid-derived suppressor cells,may serve as key links between surgical inflammation,immunosuppression,and metastatic risk.Studies on local anesthetics such as lidocaine further suggest that the potential anti-tumor effect of perioperative drugs should not be understood solely from the perspective of direct tumor cell inhibition,but rather through their modulation of the immune microenvironment.Drawing on recent advances in basic,translational,and clinical research,this review discusses the relationship among anesthesia in tumor surgery,perioperative immune microenvironment modulation,and postoperative recurrence prevention,and proposes future research directions.关键词
围手术期医学/肿瘤免疫微环境/炎症反应/麻醉/肿瘤相关巨噬细胞/利多卡因/术后复发Key words
perioperative medicine/tumor immune microenvironment/inflammatory response/anesthesia/tumor-associated macrophages/lidocaine/postoperative recurrence引用本文复制引用
刘泽宇,李泉..肿瘤手术麻醉:围手术期免疫微环境调控与术后复发预防[J].感染、炎症、修复,2026,27(4):422-426,5.基金项目
广东省自然科学基金面上项目(2025A1515011341) （2025A1515011341）
深圳市"医疗卫生三名工程"项目(SZSM202311003) （SZSM202311003）
