首页|期刊导航|动物学研究|AI-aided design of multi-epitope peptide vaccine elicits cellular and humoral immunity to broad Omicron subvariants

AI-aided design of multi-epitope peptide vaccine elicits cellular and humoral immunity to broad Omicron subvariants

Kai Zhang Xinxin Zhang Jing Chen Guangyu Zhao Xingchao Geng Yiru Long Likun Gong Gangao Wang Tingting Liu Min Li Longfei Ding Yanqi Zhao Jianqing Xu Honglin Li Jianhua Sun

动物学研究2026，Vol.47Issue(3)：851-865,15.

动物学研究2026，Vol.47Issue(3)：851-865,15.DOI:10.24272/j.issn.2095-8137.2025.469

AI-aided design of multi-epitope peptide vaccine elicits cellular and humoral immunity to broad Omicron subvariants

Kai Zhang ¹Xinxin Zhang ²Jing Chen ¹Guangyu Zhao ³Xingchao Geng ⁴Yiru Long ⁵Likun Gong ⁶Gangao Wang ⁷Tingting Liu ⁵Min Li ³Longfei Ding ⁸Yanqi Zhao ²Jianqing Xu ⁸Honglin Li ⁷Jianhua Sun⁹

作者信息

1. School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China||State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China
2. Shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai,Shandong 264117,China
3. State Key Laboratory of Pathogen and Biosecurity,Academy of Military Medical Sciences,Beijing 100071,China
4. Institute for Biological Product Control,National Institutes for Food and Drug Control,Beijing 100176,China
5. State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China
6. School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China||State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China||Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan,Guangdong 528400,China
7. Innovation Center for AI and Drug Discovery,School of Pharmacy,East China Normal University,Shanghai 200062,China
8. Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences,Fudan University,Shanghai 201508,China
9. State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China||Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan,Guangdong 528400,China
折叠

摘要

关键词

Peptide vaccine/AI-aided design/SARS-CoV-2/T-and B-cell epitopes

Key words

Peptide vaccine/AI-aided design/SARS-CoV-2/T-and B-cell epitopes

引用本文复制引用

Kai Zhang,Xinxin Zhang,Jing Chen,Guangyu Zhao,Xingchao Geng,Yiru Long,Likun Gong,Gangao Wang,Tingting Liu,Min Li,Longfei Ding,Yanqi Zhao,Jianqing Xu,Honglin Li,Jianhua Sun..AI-aided design of multi-epitope peptide vaccine elicits cellular and humoral immunity to broad Omicron subvariants[J].动物学研究,2026,47(3):851-865,15.

基金项目

This work was supported by the Strategic Priority Research Program,Chinese Academy of Sciences(XDB1310302),National Key Research and Development Program of China(2022YFC2304105),National Natural Science Foundation of China(82341039),Postdoctoral Fellowship Program of CPSF(GZB20230797),and Zhongshan Municipal Bureau of Science and Technology(CXTD2023010) （XDB1310302）

动物学研究

ISSN：0254-5853

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