神经损伤与功能重建2026，Vol.21Issue(8)：476-479,496,5.DOI:10.16780/j.cnki.sjssgncj.20250556
小胶质细胞TREM2在阿尔茨海默病及其他神经退行性疾病中保护作用研究进展
Advances in the Protective Role of Microglial TREM2 in Alzheimer's Disease and Other Neurodegenerative Diseases
摘要
Abstract
As global population aging intensifies,the rising incidence of neurodegenerative diseases poses a significant public health challenge.TREM2(triggering receptor expressed on myeloid cells 2),an immune regulatory receptor specifically expressed in microglia,plays a dual role in neurodegenerative diseases by modulating phagocytosis,inflammatory responses,and cell metabolism.TREM2 can recognize damaged neurons and pathological proteins,such as β-amyloid.It then activates downstream signaling pathways like PI3K/Akt,driving microglia to an anti-inflammatory phenotype.This process clears toxic substances and maintains neuronal metabolic homeostasis.However,TREM2 gene mutations can lead to abnormal protein function,substantially increasing Alzheimer's disease risk.This paper comprehensively reviews TREM2's role in various neurodegenerative diseases,particularly in Alzheimer's disease,aiming to underpin the development of TREM2-based therapies with theoretical evidence and novel insights.关键词
神经退行性疾病/小胶质细胞/髓系细胞触发受体2Key words
neurodegenerative diseases/Microglia/TREM2分类
医药卫生引用本文复制引用
燕润泽,王玥,赵丽..小胶质细胞TREM2在阿尔茨海默病及其他神经退行性疾病中保护作用研究进展[J].神经损伤与功能重建,2026,21(8):476-479,496,5.基金项目
国家自然科学基金项目(TREM2调控DAM在1型糖尿病认知功能障碍中作用及其机制,No.82071539) （TREM2调控DAM在1型糖尿病认知功能障碍中作用及其机制,No.82071539）
北京市自然科学基金项目(TREM2介导小胶质细胞自噬减轻1型糖尿病认知功能障碍的作用及机制,No.7232003) （TREM2介导小胶质细胞自噬减轻1型糖尿病认知功能障碍的作用及机制,No.7232003）
