广西科学院学报2026，Vol.42Issue(2)：240-248,9.DOI:10.13657/j.cnki.gxkxyxb.20260105.001
两种二氢杨梅素-酚酸共晶的制备、表征和性质研究
Preparation,Characterization and Properties of Two Dihydro-myricetin-Phenolic Acid Cocrystals
摘要
Abstract
To improve the low bioavailability caused by the low solubility of dihydromyricetin(DHM),DHM was selected as the active component of the drug,and rhein(RH)and Vanillic Acid(VA)were used as the cocrystal forming agents in this study.Two new types of drug cocrystals were successfully prepared using cooling crystallization and solvent evaporation techniques.The obtained cocrystals were characterized by Powder X-ray Diffraction(PXRD),Fourier Transform Infrared spectroscopy(FT-IR),Differential Scanning Calorimetry(DSC),Thermogravimetric(TG)and proton Nuclear Magnetic Rresonance spectra(1H-NMR),and the solubility of the drug cocrystals was investigated simultaneously.The results showed that new dif-fraction peaks appeared in the PXRD patterns of the two pharmaceutical cocrystals,and characteristic func-tional group shifts were observed in their FT-IR spectra.In the DSC curve,the endothermic peak of the drug cocrystal was different from that of DHM.The results of 1H-NMR showed that the stoichiometric ratios of DHM-RH cocrystal and DHM-VA cocrystal were 1:2 and 1:1,respectively.In the in vitro dissolution ex-periment study,compared with DHM,the dissolution rates of the two drug cocrystals were significantly im-proved.The drug cocrystal synthesis strategy in this study can provide a reference for the development of tra-ditional Chinese medicine preparations.关键词
药物共晶/二氢杨梅素/大黄酸/香草酸/溶解度Key words
drug cocrystal/dihydromyricetin/rhein/vanillic acid/solubility分类
化学化工引用本文复制引用
陈新科,李静萍,刘亚男,蒋才武..两种二氢杨梅素-酚酸共晶的制备、表征和性质研究[J].广西科学院学报,2026,42(2):240-248,9.基金项目
国家自然科学基金项目(20662002),广西自然科学基金面上项目(2023GXNSFAA026292)和广西壮瑶药重点实验室开放课题(桂科基字〔2014〕32号)资助. （20662002）
