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Age-associated immune dysregulation links to disease severity in macrolide-resistant Mycoplasma pneumoniae pneumonia:Insights from a comparative juvenile-adult mouse model

Xuejun Li Hongji Wu Fei Zhao Yan Ma Yibai Xiong Yudong Wang Liyong Liu Mengmeng Gong Jinlong Wang Yuqing Cao Zhixin Sun Fanliang Meng Qiuyan Wang

动物模型与实验医学（英文）2026，Vol.9Issue(8)：1489-1506,18.

动物模型与实验医学（英文）2026，Vol.9Issue(8)：1489-1506,18.DOI:10.1002/ame2.70231

Age-associated immune dysregulation links to disease severity in macrolide-resistant Mycoplasma pneumoniae pneumonia:Insights from a comparative juvenile-adult mouse model

Xuejun Li ¹Hongji Wu ²Fei Zhao ³Yan Ma ⁴Yibai Xiong ⁵Yudong Wang ⁵Liyong Liu ³Mengmeng Gong ⁴Jinlong Wang ⁶Yuqing Cao ⁴Zhixin Sun ⁵Fanliang Meng ³Qiuyan Wang²

作者信息

1. Pediatric Hospital,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,China||Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China
2. Pediatric Hospital,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,China
3. National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease,Beijing,China
4. Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing,China
5. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China
6. Changping Laboratory,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
折叠

摘要

关键词

adaptive immunity/age-associated susceptibility/inflammatory response/innate immunity/juvenile mice/macrolide-resistant Mycoplasma pneumoniae pneumonia

Key words

adaptive immunity/age-associated susceptibility/inflammatory response/innate immunity/juvenile mice/macrolide-resistant Mycoplasma pneumoniae pneumonia

引用本文复制引用

Xuejun Li,Hongji Wu,Fei Zhao,Yan Ma,Yibai Xiong,Yudong Wang,Liyong Liu,Mengmeng Gong,Jinlong Wang,Yuqing Cao,Zhixin Sun,Fanliang Meng,Qiuyan Wang..Age-associated immune dysregulation links to disease severity in macrolide-resistant Mycoplasma pneumoniae pneumonia:Insights from a comparative juvenile-adult mouse model[J].动物模型与实验医学（英文）,2026,9(8):1489-1506,18.

基金项目

This research was supported by the 2024 Key Project of the National Key R&D Program"Modernization of Traditional Chinese Medicine"(2024YFC3506004),National Natural Science Foundation of China(NSFC)Youth Fund Project(82405474,82505668),The 77th Batch of General Funding Projects from the China Postdoctoral Science Foundation(2025M773953),Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(no.:CI2023C005),the Second Batch of Discipline Construction Projects for Traditional Chinese Medicine in Henan Province's Characteristic Key Disciplines(no.:STG-ZYX05-202140),and Special Scientific Research Project for the Creation of"Double First Class"Traditional Chinese Medicine in Henan Province(no.:HSRP-DFCTCM-2023-8-10). （2024YFC3506004）

动物模型与实验医学（英文）

ISSN：2096-5451

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