动物模型与实验医学（英文）2026，Vol.9Issue(8)：1648-1660,13.DOI:10.1002/ame2.70154
One-step generation of heritable mitochondrial DNA multiplex-engineered rats using DddA-derived cytosine base editor
One-step generation of heritable mitochondrial DNA multiplex-engineered rats using DddA-derived cytosine base editor
Xu Zhang 1Gefan Wan 1Wei Dong 1Weining Kong 1Bin Shen 2Xiaolong Qi 3Yuanwu Ma 4Keru Li 1Lei Tan 2Wei Chen 1Shan Gao 1Chenyang Liu 1Shuo Pan 1Jiayue He 1Ning Liu1
作者信息
- 1. State Key Laboratory of Respiratory Health and Multimorbidity,NHC Key Laboratory of Human Disease Comparative Medicine,Key Laboratory of Pathogen Infection Prevention and Control Ministry of Education,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China
- 2. State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu,China
- 3. State Key Laboratory of Respiratory Health and Multimorbidity,NHC Key Laboratory of Human Disease Comparative Medicine,Key Laboratory of Pathogen Infection Prevention and Control Ministry of Education,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China||National Human Diseases Animal Model Resource Center and National Center of Technology Innovation for Animal Model,Haihe Laboratory of Cell Ecosystem,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China
- 4. State Key Laboratory of Respiratory Health and Multimorbidity,NHC Key Laboratory of Human Disease Comparative Medicine,Key Laboratory of Pathogen Infection Prevention and Control Ministry of Education,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China||National Human Diseases Animal Model Resource Center and National Center of Technology Innovation for Animal Model,Haihe Laboratory of Cell Ecosystem,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China||Medical Primate Research Center and Neuroscience Center,Chinese Academy of Medical Sciences,Beijing,China
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摘要
关键词
DdCBE/mtDNA/mutation/ratKey words
DdCBE/mtDNA/mutation/rat引用本文复制引用
Xu Zhang,Gefan Wan,Wei Dong,Weining Kong,Bin Shen,Xiaolong Qi,Yuanwu Ma,Keru Li,Lei Tan,Wei Chen,Shan Gao,Chenyang Liu,Shuo Pan,Jiayue He,Ning Liu..One-step generation of heritable mitochondrial DNA multiplex-engineered rats using DddA-derived cytosine base editor[J].动物模型与实验医学（英文）,2026,9(8):1648-1660,13.基金项目
This work was supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-024,2022-I2M-1-020,and 2023-I2M-2-001) （2021-I2M-1-024,2022-I2M-1-020,and 2023-I2M-2-001）
the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2023-PT180-01) （2023-PT180-01）
Haihe Laboratory of Cell Ecosystem Innovation Fund(HH24KYZX0007) （HH24KYZX0007）
Open Research Project in State Key Laboratory of Vascular Homeostasis and Remodeling(Peking University)(202411) （Peking University）
State Key Laboratory Special Fund(2060204) （2060204）
the National Key R&D Program of China(2022YFF0710702). （2022YFF0710702）
