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Rapid trapping and label-free optical characterization of single nanoscale extracellular vesicles and nanoparticles in solution

Ikjun Hong Chuchuan Hong Theodore Anyika Guodong Zhu Maxwell Ugwu James N.Higginbotham Jeffrey L.Franklin Robert Coffey Justus C.Ndukaife

光：科学与应用（英文版）2026，Vol.15Issue(7)：2205-2216,12.

光：科学与应用（英文版）2026，Vol.15Issue(7)：2205-2216,12.DOI:10.1038/s41377-026-02201-z

Rapid trapping and label-free optical characterization of single nanoscale extracellular vesicles and nanoparticles in solution

Ikjun Hong ¹Chuchuan Hong ²Theodore Anyika ¹Guodong Zhu ¹Maxwell Ugwu ³James N.Higginbotham ⁴Jeffrey L.Franklin ⁵Robert Coffey ⁵Justus C.Ndukaife⁶

作者信息

1. Vanderbilt Institute of Nanoscale Science and Engineering,Vanderbilt University,Nashville,TN,USA||Department of Electrical and Computer Engineering,Vanderbilt University,Nashville,TN,USA
2. Department of Chemistry,Northwestern University,Evanston,IL,USA
3. Vanderbilt Institute of Nanoscale Science and Engineering,Vanderbilt University,Nashville,TN,USA||Interdisciplinary Materials Science and Engineering,Vanderbilt University,Nashville,TN,USA
4. Department of Medicine,Vanderbilt University Medical Center,Nashville,TN,USA||Center for Extracellular Vesicles Research,Vanderbilt University,Nashville,TN,USA||Epithelial Biology Center,Vanderbilt University Medical Center,Nashville,TN,USA
5. Department of Medicine,Vanderbilt University Medical Center,Nashville,TN,USA||Center for Extracellular Vesicles Research,Vanderbilt University,Nashville,TN,USA||Epithelial Biology Center,Vanderbilt University Medical Center,Nashville,TN,USA||Department of Cell and Developmental Biology,Vanderbilt University,Nashville,TN,USA
6. Vanderbilt Institute of Nanoscale Science and Engineering,Vanderbilt University,Nashville,TN,USA||Department of Electrical and Computer Engineering,Vanderbilt University,Nashville,TN,USA||Interdisciplinary Materials Science and Engineering,Vanderbilt University,Nashville,TN,USA||Center for Extracellular Vesicles Research,Vanderbilt University,Nashville,TN,USA||Department of Mechanical Engineering,Vanderbilt University,Nashville,TN,USA
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摘要

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Ikjun Hong,Chuchuan Hong,Theodore Anyika,Guodong Zhu,Maxwell Ugwu,James N.Higginbotham,Jeffrey L.Franklin,Robert Coffey,Justus C.Ndukaife..Rapid trapping and label-free optical characterization of single nanoscale extracellular vesicles and nanoparticles in solution[J].光：科学与应用（英文版）,2026,15(7):2205-2216,12.

基金项目

The authors acknowledge financial support from the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R35GM150572.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.Fabrication of the nanostructure was conducted at the Vanderbilt Institute of Nanoscale Science and Engineering cleanroom facility.This work was made possible in part through access to shared resources,equipment,and the collaborative research environment provided by the Vanderbilt Center for Extracellular Vesicle Research. （）

光：科学与应用（英文版）

ISSN：2095-5545

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