医学分子生物学杂志2026，Vol.23Issue(4)：431-436,6.DOI:10.3870/j.issn.1672-8009.2026.04.009
丹皮酚对慢性不可预知温和应激诱导的抑郁症大鼠空间学习记忆和抑郁样行为的影响及机制
Effect and Mechanism of Paeonol on Spatial Learning,Memory and Depression-Like Behavior in Rats with Chronic Unpredictable Mild Stress-induced Depression
摘要
Abstract
Objective To analyze the effect of paeonol on spatial learning,memory and de-pression-like behavior in rats with chronic unpredictable mild stress(CUMS)-induced depression,and to explore its mechanism.Methods The CUMS-induced depression rats were divided into 5 groups:depression group,low-dose,medium-dose and high-dose paeonol groups and Flu group,and the control group was set up.Drug intervention was administered during the third week of stress and continued for one week;rats in the control group received no treatment.The Morris water maze,sucrose preference test,forced swimming test(FST)and tail suspension test(TST)were con-ducted.The levels of serum CRH,ACTH and CORT,and the expression levels of ERK/CREB pro-teins in hippocampus were detected.Results Compared with those in the control group,the su-crose preference of rats in the depression group was declined(P＜0.05),the escape latency was prolonged,the times of platform crossings and residence time in the third quadrant were decreased(P＜0.05),the immobility time in the FST and TST was increased(P＜0.05),the levels of ser-um CRH,ACTH and CORT were increased(P＜0.05),and ratios of p-ERK/ERK and p-CREB/CREB in the hippocampus were decreased(P＜0.05).Compared with those in the depression group,the above indexes were significantly reversed in rats of the medium-and high-dose paeonol groups and the Flu group(P＜0.05).Conclusion Paeonol can improve spatial learning,memo-ry ability and depression-like behavior in rats with CUMS-induced depression,and the mechanism is related to regulation of HPA and ERK/CREB signaling pathways.关键词
抑郁症/慢性不可预知温和应激/丹皮酚/细胞外信号调节激酶/环磷酸腺苷反应元件结合蛋白Key words
depression/chronic unpredictable mild stress/paeonol/extracellular signal-reg-ulated kinase/cAMP-response element binding protein分类
医药卫生引用本文复制引用
李卫,毕翻,王凯,曾云,郭志伟..丹皮酚对慢性不可预知温和应激诱导的抑郁症大鼠空间学习记忆和抑郁样行为的影响及机制[J].医学分子生物学杂志,2026,23(4):431-436,6.基金项目
四川省医学(青年创新)科研项目(No.Q20043) This work was supported by a grant from the Sichuan Province Medical(Youth Innovation)Research Project(No.Q20043). （青年创新）
