医学分子生物学杂志2026，Vol.23Issue(4)：437-444,8.DOI:10.3870/j.issn.1672-8009.2026.04.010
白芍总苷改善百草枯致大鼠肺损伤及纤维化
Improvement of Paraquat-induced Lung Injury and Fibrosis by Total Glucosides of Paeonia in Rats
摘要
Abstract
Objective To explore the effects of total glucosides of paeony(TGP)on oxidative stress and lung fibrosis in rats with paraquat(PQ)-induced lung injury.Methods Intraperitoneal injection of PQ was performed to induce lung injury in rats,then those rats were intervened with dif-ferent doses of TGP.The pathological changes of lung tissues,oxidative stress,levels of inflamma-tory factors,mRNA levels of fibrosis-related factors and expressions of TGF-β1/Smad3 signaling pathway proteins were observed.RLE-6TN cells were treated with PQ and intervened with TGP.The expression levels of TGF-β1/Smad3 pathway related factors in cells were detected.Results After TGP intervention,the lung injury,the levels of MDA and HYP,the levels of serum TNF-α,IL-6 and IL-1β,the mRNA expression levels of α-SMA,Collagen Ⅲ and TIMP-1,and the expression levels of TGF-β1 and p-Smad3/Smad3 were decreased,while the levels of SOD and CAT,and the ratio of p-Smad7/Smad7 were increased,in a dose-dependent manner.After TGP intervention,the expression level of p-Smad7 in RLE-6TN cells was increased,while the expression levels of TGF-β1 and p-Smad3 were decreased.Conclusion TGP can improve oxidative stress and lung fibrosis in PQ rats.The mechanism may be related to TGF-β1/Smad3 signaling pathways.关键词
百草枯/肺损伤/白芍总苷/氧化应激/肺纤维化Key words
paraquat/lung injury/total glucosides of paeonia/oxidative stress/lung fibrosis分类
医药卫生引用本文复制引用
刘梅,司永旺,刘丽,崔春叶,王丹,洛莹莹..白芍总苷改善百草枯致大鼠肺损伤及纤维化[J].医学分子生物学杂志,2026,23(4):437-444,8.基金项目
河北省医学科学研究课题(20250244) This work was supported by a grant from the Medical Science Research Project of Hebei Province(20250244). （20250244）
