医学分子生物学杂志2026，Vol.23Issue(4)：452-457,6.DOI:10.3870/j.issn.1672-8009.2026.04.012
罗哌卡因在小鼠过敏性鼻炎模型中的治疗作用及机制
Therapeutic Effect and Mechanism of Ropivacaine in Mice Model of Allergic Rhinitis
王欢 1张贺 2殷萌 3张惠男 1刘光 1郭继峰1
作者信息
- 1. 首都医科大学附属北京儿童医院保定医院 手术麻醉科 河北省保定市,071000
- 2. 首都医科大学附属北京儿童医院保定医院 呼吸科 河北省保定市,071000
- 3. 中国中医科学院广安门医院保定医院麻醉科 河北省保定市,071000
- 折叠
摘要
Abstract
Objective To explore the effect of ropivacaine on alleviating ovalbumin(OVA)-induced allergic rhinitis(AR)in mice.Methods Mice were randomly divided into 5 groups:control group,AR group,low-dose Ropivacaine group(1 mg/kg),high-dose Ropivacaine group(5 mg/kg)and Dexamethasone(Dex)positive group(2 mg/kg),with 5 mice in each group.Indicator evaluations were conducted after the last drug administration.Results The body weight of mice in the high-dose Ropivacaine group and Dex group was greater than that in the AR group(P＜0.05),and the relative spleen weight,the times of nose rubbing,sneezing and runny nose,levels of serum histamine,OVA-specific immunoglobulin E(IgE),total IgE,total IgG1 and β-hexosaminidase,levels of iIL-1β,IL-6,TNF-α,IL-4 and IL-5 in nasal lavage fluid and the protein expression levels of p65 and p-IkBα in the nasal mucosa were lower than those in the AR group(P＜0.05).Eosinophil infiltration was reduced.Conclusion High-dose ropivacaine can re-lieve OVA-induced rhinitis symptoms and inflammatory infiltration of nasal mucosa of mice with AR.The mechanism may be related to the inhibition of NF-κB signaling pathway.关键词
罗哌卡因/卵清蛋白/过敏性鼻炎/细胞因子/NF-κB信号通路Key words
ropivacaine/ovalbumin/allergic rhinitis/cytokines/NF-κB signaling pathway分类
医药卫生引用本文复制引用
王欢,张贺,殷萌,张惠男,刘光,郭继峰..罗哌卡因在小鼠过敏性鼻炎模型中的治疗作用及机制[J].医学分子生物学杂志,2026,23(4):452-457,6.
