医学分子生物学杂志2026，Vol.23Issue(4)：466-470,5.DOI:10.3870/j.issn.1672-8009.2026.04.014
Plk1在神经退行性疾病中的研究进展
Research Progress on Plk1 in Neurodegenerative Diseases
摘要
Abstract
As a key member of the serine/threonine protein kinase family,Polo-like kinase 1(Plk1)is a core regulator of the cell cycle,whose dysfunction is closely related to tumorigene-sis.Recent research has found that Plk1 is abnormally expressed in terminally differentiated neurons and is closely associated with the pathological processes of neurodegenerative diseases such as Alzhe-imer's disease,Parkinson's disease and amyotrophic lateral sclerosis.It is particularly noteworthy that Plk1 plays a dual role in diseases like Alzheimer's:it not only directly mediates neuronal death by driving aberrant cell cycle re-entry but also participates in regulating neuroprotective processes such as autophagy.The complex role of Plk1 in neurodegenerative diseases,particularly its seeming-ly contradictory dual function,offers a new perspective for understanding the mechanisms underlying neurodegenerative disorders and developing novel therapeutic strategies.关键词
Plk1/神经退行性疾病/阿尔茨海默病/帕金森病/肌萎缩侧索硬化症Key words
Polo-like kinase 1/neurodegenerative diseases/Alzheimer's disease/Parkin-son's disease/amyotrophic lateral sclerosis分类
生物科学引用本文复制引用
陈雨柔,于楠,李伟..Plk1在神经退行性疾病中的研究进展[J].医学分子生物学杂志,2026,23(4):466-470,5.基金项目
国家自然科学基金(No.81602796) This work was supported by a grant from the National Natural Science Foundation of China(No.81602796). （No.81602796）
