华侨大学学报（自然科学版）2026，Vol.47Issue(5)：571-581,11.DOI:10.11830/ISSN.1000-5013.202503035
虾青素微囊粉制备工艺优化及其初步体外评价
Preparation Process Optimization and In Vitro Preliminary Evaluation of Astaxanthin Microcapsule Powder
摘要
Abstract
Astaxanthin microcapsule powder(Asta-MCs)was prepared using spray drying method,and its process parameters were optimized.An ultravioletin vitro analytical method for astaxanthin(Asta)was estab-lished,and the process was optimized through single-factor tests using encapsulation efficiency,retention rate and particle size as evaluation indices.The optimal process was finally determined that,octenyl succinic an-hydride starch ester(OSA)-hydroxypropyl-β-cyclodextrin(H-β-CD)-maltodextrin(MD)served as wall materi-als with mass ratio of 6∶3∶2,the solid mass fraction was 25%,and the wall to core mass ratio was 3∶1.Thein vitro preliminary evaluation was carried out by performing in vitro dissolution experiments and diges-tive simulation experiments of Asta-MCs,and the bioaccessibility rate and antioxidant capacity were investiga-ted.The results showed that,Asta-MCs had significant advantages in dissolution rate compared with Haema-tococcus pluvialis oil(Hpo),which could improve the bioavailability of Asta.This study provides strong support for the application of Asta-MCs in drug delivery and bioavailability.关键词
虾青素微囊粉/喷雾干燥/工艺优化/体外模拟消化Key words
astaxanthin microencapsulated powder/spray drying/process optimization/in vitro simulated di-gestion分类
医药卫生引用本文复制引用
许晓英,冯云福,赵健康,刘佳,王立强,侯志勇..虾青素微囊粉制备工艺优化及其初步体外评价[J].华侨大学学报（自然科学版）,2026,47(5):571-581,11.基金项目
国家重点研发计划项目(2016YFE0101700) （2016YFE0101700）
福建省高校产学合作重大项目(2019Y4007) （2019Y4007）
华侨大学研究生科研创新基金资助项目(18013071019) （18013071019）
