海洋科学2026，Vol.50Issue(3)：86-97,12.DOI:10.11759/hykx20260119001
福建牡蛎(Crassostrea angulata)生长和粗蛋白含量性状的全基因组关联分析
Genome-wide association analysis of growth efficiency and crude protein content traits in Fujian oyster(Crassostrea an-gulata)
摘要
Abstract
The Fujian oyster(Crassostrea angulata)is an important shellfish species farmed in southern China;its growth rate and nutritional quality impact industry profitability.However,the genetic basis of key traits such as development and crude protein content remains poorly understood.To address this lacuna,we investigated 100 in-dividuals from a population cultured in Sanshan,Fuqing,Fujian Province,China,for six key traits:shell height,shell width,total weight,oyster weight,meat yield,and crude protein content.Whole-genome resequencing and genome-wide association studies were subsequently performed.All traits exhibited substantial phenotypic varia-tions(coefficient of variation:11.41%-53.21%).Growth traits were significantly positively correlated(P<0.05),but not with crude protein levels.Based on 15.9 million high-quality single-nucleotide polymorphisms(SNPs)and us-ing a mixed linear model,we detected 31 SNPs robustly associated with growth traits(-log10P≥6.0),distributed across chromosomes 1,2,5,7,9,and 10.Presumptive genes near these loci included pleiotropic genes(GCN2,FCN2,P2RX7,FER)and trait-specific genes(SMAD4 and TRIM2),primarily functioning in nutrient sensing,im-mune regulation,and growth.We also identified 15 SNPs enriched on chromosome 9 that were significantly associ-ated with crude protein content(-log10P≥9.2).In total,14 candidate genes located near these loci,including NCAN,HERC1,and SMARCA1,were involved in protein synthesis/degradation and epigenetic regulation.This study pre-liminarily screened SNPs and genes putatively associated with growth performance and crude protein contents in C.angulata.The findings provide targets and clues crucial for subsequent mechanistic genetic analyses and the identi-fication of molecular breeding markers.关键词
福建牡蛎/全基因组关联分析/生长性状/粗蛋白含量/候选基因Key words
Crassostrea angulata/genome-wide association study/growth traits/crude protein content/candidate genes分类
农业科技引用本文复制引用
王静,黄小青,林谷,林颖辉,史健志,姜延乐,史博,侯杰,阙华勇..福建牡蛎(Crassostrea angulata)生长和粗蛋白含量性状的全基因组关联分析[J].海洋科学,2026,50(3):86-97,12.基金项目
国家重点研发计划项目(2023YFD2100200) （2023YFD2100200）
福建省科技计划项目(2024N0057)National Key R&D Program of China,No.2023YFD2100200 （2024N0057）
Fujian Provincial Science and Technology Plan Project,No.2024N0057 （）
