中国当代医药2026，Vol.33Issue(21)：191-195,5.DOI:10.3969/j.issn.1674-4721.2026.21.39
呼吸道微生物群失衡在儿童肺炎支原体肺炎免疫机制中的研究进展
Research progress of respiratory microbiota imbalance in the immune mechanism of Mycoplasma pneumoniae pneumonia in children
摘要
Abstract
Mycoplasma pneumoniae pneumonia(MPP)is a common type of community-acquired pneumonia in children.Dynamic changes in the respiratory microbiota are closely related to its immunopathological mechanisms.This review summarizes the alterations in the respiratory microbiota of affected children,including decreased diversity,enrichment of potential pathogens,and reduction of beneficial bacteria.It explores how microbiota dysbiosis participates in the immunopathological process of the disease by affecting innate immune responses,regulating adaptive immune cell differen-tiation,and mediating distal regulation via the gut-lung axis,thereby influencing childhood immune development.Further-more,this review outlines novel interventions based on microbiota modulation,including therapeutic and preventive strategies as well as predictive models using microbial markers,aiming to provide new insights for clinical diagnosis and treatment of MPP.关键词
呼吸道微生物群/肺炎支原体肺炎/儿童肺炎/免疫机制/菌群失衡Key words
Respiratory microbiota/Mycoplasma pneumoniae pneumonia/Pneumonia in children/Immune mechanism/Imbalance of microbiota分类
医药卫生引用本文复制引用
戚文君,姚欢迎..呼吸道微生物群失衡在儿童肺炎支原体肺炎免疫机制中的研究进展[J].中国当代医药,2026,33(21):191-195,5.基金项目
浙江省医药卫生科技计划项目(2023KY363). （2023KY363）
