昆明医科大学学报2026，Vol.47Issue(8)：118-126,9.DOI:10.12259/j.issn.2095-610X.S20260812
外周血Gas6、IL-18BP与颅内动脉瘤术后继发认知功能障碍的关系
Association between Peripheral Blood Gas6,IL-18BP and Secondary Cognitive Impairment Following Intracranial Aneurysm Surgery
摘要
Abstract
Objective To investigate the relationship between peripheral blood growth arrest-specific protein 6(Gas6),interleukin-18 binding protein(IL-18BP)and postoperative secondary cognitive impairment in patients with intracranial aneurysms,and to analyze its predictive value for postoperative secondary cognitive impairment.Methods A total of 287 patients with intracranial aneurysm who underwent endovascular intervention at Yancheng First People's Hospital from January 2022 to May 2025 were enrolled.Based on the presence or absence of postoperative secondary cognitive dysfunction at 3 months post-operation(3 cases lost to follow-up),patients were divided into cognitive dysfunction group(n=82)and normal cognition group(n=202).Peripheral blood levels of Gas6 and IL-18BP before and after surgery were compared between the two groups.The influencing factors of postoperative secondary cognitive dysfunction in intracranial aneurysm were analyzed.The relationship between peripheral blood Gas6,IL-18BP and postoperative secondary cognitive dysfunction in intracranial aneurysm was analyzed.The predictive value of peripheral blood Gas6 and IL-18BP for postoperative secondary cognitive dysfunction in intracranial aneurysm was analyzed.Results Peripheral blood Gas6 levels in the cognitive dysfunction group were higher at postoperative day 1,3,and 7 compared with the normal cognition group,while IL-18BP levels were lower(P＜0.05).After adjusting for Hunt-Hess grade,CT Fisher grade,maximum aneurysm diameter,operation time,postoperative cerebral hemorrhage/cerebral ischemia,peripheral blood Gas6 and IL-18 BP on postoperative day 7 remained independently associated with postoperative secondary cognitive dysfunction in intracranial aneurysm(P＜0.05).Postoperative day 7 peripheral blood Gas6 levels were positively linearly correlated with postoperative secondary cognitive dysfunction in intracranial aneurysm,while IL-18BP levels were negatively linearly correlated(P＜0.05).The area under the receiver operating characteristic curve(AUC)for combined prediction of postoperative secondary cognitive dysfunction using Gas6 and IL-18BP on postoperative day 7 was significantly higher than that of single indicators(P＜0.05).Conclusion In patients with intracranial aneurysm,peripheral blood Gas6 levels are positively linearly correlated with postoperative secondary cognitive dysfunction,while IL-18BP levels are negatively linearly correlated.Combined detection of these biomarkers has predictive value for postoperative secondary cognitive dysfunction.关键词
颅内动脉瘤/认知功能障碍/生长停滞特异性蛋白6/白细胞介素18结合蛋白/预测Key words
Intracranial aneurysms/Cognitive impairment/Growth arrest-specific protein 6/Interleukin-18 binding protein/Prediction分类
医药卫生引用本文复制引用
丁亮,万政强,吴沛璋,姜乔继,罗煜宸,杨红伟..外周血Gas6、IL-18BP与颅内动脉瘤术后继发认知功能障碍的关系[J].昆明医科大学学报,2026,47(8):118-126,9.基金项目
江苏省科学技术厅省科技计划专项基金(BE2023811) （BE2023811）
