昆明医科大学学报2026，Vol.47Issue(8)：169-180,12.DOI:10.12259/j.issn.2095-610X.S20260817
中药靶向Wnt/β-catenin信号通路调控阿尔茨海默病神经炎症的研究进展
Traditional Chinese Medicine Targeting the Wnt/β-catenin Signaling Pathway to Modulate Neuroinflammation in Alzheimer's Disease
摘要
Abstract
Under the increasingly severe aging demographics,neurodegenerative diseases such as Alzheimer's disease(AD)pose serious threats to population health.AD is characterized by progressive cognitive decline and memory loss.Its pathogenic mechanisms are complex,featuring a prolonged disease course and pathological characteristics that encompass multiple aspects,including β-amyloid protein deposition,tau protein hyperphosphorylation,neuroinflamumatory responses,and oxidative stress,presenting formidable challenges for AD prevention and treatment.Currently,monoclonal antibody-based targeted therapeutics for AD not only show limited efficacy but are also associated with significant adverse effects.In contrast,traditional Chinese medicine,utilizing its multi-component and multi-target systemic regulatory advantages,exhibits unique potential in intervening in the complex pathological processes of AD,particularly in modulating neuroinflammatory responses.This article systematically reviews the central role of the Wnt/β-catenin signaling pathway in regulating neuroinflammation in Alzheimer's disease and summarizes recent research advances in the treatment of AD by traditional Chinese medicine and its active components through intervention in this pathway,aiming to provide novel theoretical evidence and strategic references for AD prevention and treatment.关键词
阿尔茨海默病/Wnt/β-catenin信号通路/中药/神经炎症Key words
Alzheimer's disease/Wnt/β-catenin signaling pathway/Traditional Chinese medicine/Neuroinflammation分类
医药卫生引用本文复制引用
方岚希,刘冠林,胡炜彦,甘平..中药靶向Wnt/β-catenin信号通路调控阿尔茨海默病神经炎症的研究进展[J].昆明医科大学学报,2026,47(8):169-180,12.基金项目
国家自然科学基金(31860272) （31860272）
云南科技厅-昆明医科大学应用基础研究联合专项基金(202201AY07000-018) （202201AY07000-018）
