口腔颌面外科杂志2026，Vol.36Issue(4)：318-324,7.DOI:10.12439/kqhm.1005-4979.2026.04.007
白蛋白水平与颌面部间隙感染严重程度的相关性分析
Correlation analysis between albumin levels and the severity of maxillofacial space infection
摘要
Abstract
Objective:To investigate the association between serum albumin(ALB)levels at admission and the disease severity and prognosis of patients with maxillofacial space infection(MSI),and to analyze the risk factors for prolonged length of hospital stay(LOS).Methods:A retrospective analysis was conducted on the clinical data of 154 patients with MSI admitted to Qilu Hospital of Shandong University from January 1,2022,to December 31,2024.Based on the initial serum ALB level measured at admission,the patients were divided into three groups:<30 g/L,30‒35 g/L,and>35 g/L.The clinical characteristics were compared among the three ALB groups.Univariate analysis was performed to evaluate the association of clinical characteristics and ALB levels with prolonged length of hospital stay(LOS>14 days)and in-hospital mortality.Variables with P<0.05 in the univariate analysis,as well as variables considered clinically meaningful were subsequently included in multivariate logistic regression analysis to identify independent risk factors for prolonged LOS.Results:A total of 154 patients were included,of whom 141(91.6％)survived and 13(8.4％)died.26 patients(16.9％)had a prolonged LOS(>14 days).Serum ALB levels were significantly associated with age,number of involved fascial spaces,neutrophil percentage,white blood cell count,and prealbumin level(all P<0.05).Lower ALB levels were associated with a higher incidence of prolonged LOS(χ2=14.033,P<0.001)and increased in-hospital mortality(χ2=11.565,P=0.003).Multivariate logistic regression analysis demonstrated that,after adjustment for age,number of involved fascial spaces,descending necrotizing mediastinitis(DNM),surgical treatment,and neutrophil percentage,patients with ALB levels of 30‒35 g/L(OR=0.22,95％CI:0.07-0.73,P=0.013)and>35 g/L(OR=0.13,95％CI:0.03-0.48,P=0.002)had significantly lower risks of prolonged LOS compared with those with ALB levels<30 g/L,indicating that lower ALB level was an independent predictor of prolonged LOS.Conclusion:Low serum ALB level at admission was significantly associated with prolonged LOS and increased risk of in-hospital mortality in patients with MSI,and was identified as an independent risk factor for prolonged LOS.Serum ALB may serve as a simple and practical biomarker for assessing disease severity and prognosis in MSI,facilitating early risk stratification and aiding in the formulation of individualized treatment strategies in clinical practice.关键词
白蛋白/颌面部间隙感染/危险因素/住院时间/多因素Logistic回归分析Key words
albumin/maxillofacial space infection/risk factors/length of hospital stay/multivariate logistic regression analysis分类
医药卫生引用本文复制引用
周相宇,石燕然,李萧倩,王荣,彭艺琳,李兴旺,石亮..白蛋白水平与颌面部间隙感染严重程度的相关性分析[J].口腔颌面外科杂志,2026,36(4):318-324,7.基金项目
山东省自然科学基金项目(ZR2020MH187) （ZR2020MH187）
