军事医学2026，Vol.50Issue(7)：535-540,6.DOI:10.7644/j.issn.1674-9960.2025-00240
氯离子耐受型复方过氧化氢消毒剂的消毒效果及安全性评价
Efficacy and safety of a chloride ion-tolerant compound hydrogen peroxide disinfectant
摘要
Abstract
Objective To evaluate the efficacy and biosafety of a chloride ion-tolerant compound hydrogen peroxide disinfectant.Methods The efficacy of the compound hydrogen peroxide disinfectant was assessed using suspension quantitative bactericidal tests,inanimate surface disinfection tests,and air disinfection tests,respectively.Its biosafety was evaluated using animal toxicity test methods,including the acute oral toxicity test,single intact skin irritation test,and mouse bone marrow polychromatic erythrocyte micronucleus test.Results At 20℃,the log reduction value(LRV)of the disinfectant diluted with the standard hard water exceeded 3.00 against four test microorganisms(E.coli,S.aureus,P.aeruginosa,and C.albicans)within 5 minutes.When sprayed onto wooden surfaces,the diluted disinfectant yielded an average LRV of over 1.00 against natural bacteria.The germicidal efficiency against S.albus was≥99.90%in simulated air disinfection tests,and its bactericidal efficiency against airborne natural bacteria exceeded 90%after 30 minutes of exposure.The animal toxicity test results indicated that the compound hydrogen peroxide disinfectant was practically non-toxic,non-irritating to the skin,and negative in the mouse bone marrow micronucleus assay.Conclusion The disinfectant proves to be highly tolerant of chloride ions and quite safe,with rapid and broad-spectrum bactericidal efficacy after dilution with standard hard water.关键词
复方过氧化氢消毒剂/银离子/氯离子耐受/消毒效果/安全性Key words
compound hydrogen peroxide disinfectant/silver ion/chloride tolerance/disinfection efficacy/safety分类
医药卫生引用本文复制引用
杨文杰,韩杰,丁俊杰,张伯寒,李林,李志平..氯离子耐受型复方过氧化氢消毒剂的消毒效果及安全性评价[J].军事医学,2026,50(7):535-540,6.基金项目
国家重点研发计划(2022YFC2604000) （2022YFC2604000）
