国际眼科杂志2026，Vol.26Issue(9)：1598-1602,5.DOI:10.3980/j.issn.1672-5123.2026.9.16
蒸发过强型干眼发病机制研究进展
Recent advances in the pathogenesis of evaporative dry eye disease
黄艺赟 1王雁 2李小龙 2乃依拉·肖开提 1赵勇2
作者信息
- 1. (830000)中国新疆维吾尔自治区乌鲁木齐市,新疆医科大学第四临床医学院
- 2. (830000)中国新疆维吾尔自治区乌鲁木齐市,新疆医科大学第四附属医院眼科||(830000)中国新疆维吾尔自治区乌鲁木齐市,新疆维吾尔自治区眼视光临床医学中心
- 折叠
摘要
Abstract
·The ocular surface must maintain homeostasis to withstand continuous environmental stimuli,while increased tear evaporation represents a critical initiating event in the progression of evaporative dry eye disease.The composition,distribution,and function of the tear film lipid layer determine its anti-evaporative capacity.Multiple factors,including meibomian gland dysfunction,abnormalities of the lipid layer,blinking disorders,mucin deficiency,and epithelial barrier impairment,collectively weaken the evaporative barrier,subsequently inducing hyperosmotic stress and ocular surface inflammation,activating neuro-immune pathways,and thereby establishing a self-perpetuating cycle and contributing to disease chronicity.The environmental characteristics of northwestern regions,including low humidity,limited rainfall,strong winds,frequent windblown dust,and high evaporation rates,may further exacerbate these processes.This review integrates modern ocular surface pathological mechanisms with the theory of"Northwest dryness syndrome"to summarize the pathogenesis of evaporative dry eye disease and the effects of dry environmental exposure,aiming to provide a reference for risk assessment and intervention strategies for dry eye in Northwest China.关键词
干眼/发病机制/干燥环境/西北燥证Key words
dry eye disease/pathogenesis/dry environment/Northwest dryness syndrome引用本文复制引用
黄艺赟,王雁,李小龙,乃依拉·肖开提,赵勇..蒸发过强型干眼发病机制研究进展[J].国际眼科杂志,2026,26(9):1598-1602,5.
