国际眼科杂志2026，Vol.26Issue(9)：1603-1608,6.DOI:10.3980/j.issn.1672-5123.2026.9.17
OCT影像学特征预测康柏西普治疗糖尿病性黄斑水肿预后的价值
Value of OCT imaging features in predicting the prognosis of Conbercept therapy for diabetic macular edema
摘要
Abstract
·AIM:To explore the value of optical coherence tomography(OCT)imaging features in predicting the prognosis of intravitreal injection of conbercept in the treatment of diabetic macular edema(DME). ·METHODS:A retrospective selection was made of patients with DME who underwent intravitreal injection of conbercept at the hospital from July 2021 to August 2024.All patients received intravitreal injection of conbercept once a month for a total of 3 mo.OCT and best corrected visual acuity(BCVA)examinations were conducted at 4 mo after the treatment.The change in BCVA at 4 mo post-treatment served as the primary efficacy evaluation metric,with patients achieving a 2-line or greater improvement classified into the favorable prognosis group,while those with less than a 2-line improvement were categorized into the unfavorable prognosis group.Clinical data and OCT-related imaging features of the two groups were collected,and the factors influencing the unfavorable prognosis of patients treated with conbercept for DME and the predictive value of OCT-related imaging features for treatment efficacy were analyzed. ·RESULTS:A total of 115 DME patients(115 eyes)were included in this study[for patients with bilateral DME,only the eye with greater central macular thickness(CMT)was included].After 4 mo of treatment,78 cases(78 eyes)were in the good prognosis group,including 45 males and 33 females,with an average age of 60.57±7.46 y.There were 37 cases(37 eyes)in the poor prognosis group,including 24 males and 13 females,with an average age of 59.36±8.72 y.The poor prognosis rate was 32.2％.The BCVA and CMT before treatment in the poor prognosis group were higher than those in the good prognosis group(all P＜0.05).The proportions of ELM integrity destruction,EZ integrity destruction,and retinal inner layer structure disorder in the poor prognosis group were all higher than those in the good prognosis group(all P＜0.05).The factors influencing the prognosis of DME patients treated with conbercept were pre-treatment CMT(OR=1.030,P＜0.001),ELM integrity destruction(OR=22.475,P=0.002),EZ integrity destruction(OR=23.584,P=0.001),and retinal inner layer structure disorder(OR=7.901,P=0.016).The AUC values for predicting poor prognosis of DME patients treated with conbercept by each of the indicators of ELM integrity destruction,EZ integrity destruction,and retinal inner layer structure disorder alone and in combination were 0.699,0.653,0.637,and 0.843,respectively. ·CONCLUSION:Clinically,OCT examination should be emphasized in patients with DME.In the early stage,by identifying high-risk imaging features,the prognosis of DME patients can be evaluated,providing objective evidence for the formulation of individualized treatment plans.关键词
糖尿病性黄斑水肿/光学相干断层扫描(OCT)/抗血管内皮生长因子/康柏西普/预测价值Key words
diabetic macular edema/optical coherence tomography(OCT)/anti-vascular endothelial growth factor/conbercept/predictive value引用本文复制引用
张瑶,许立帅..OCT影像学特征预测康柏西普治疗糖尿病性黄斑水肿预后的价值[J].国际眼科杂志,2026,26(9):1603-1608,6.基金项目
川北医学院附属医院科技发展计划项目(No.2022LC023) Science and Technology Development Program of Affiliated Hospital of North Sichuan Medical College(No.2022LC023) （No.2022LC023）
