摘要
Abstract
·AIM:To compare the consistency of macular microvascular parameters measured by three devices:frequency-domain optical coherence tomography angiography(FD-OCTA)with split-spectrum amplitude-decorrelation angiography(SSADA),FD-OCTA with optical microangiography(OMAG),and swept-source OCTA(SS-OCTA),in patients with long-term hydroxychloroquine(HCQ)administration for rheumatoid arthritis(RA).
·METHODS:This prospective study enrolled patients treated with HCQ for 5 y due to RA who visited the Department of Ophthalmology of the hospital from January 2022 to November 2025.All subjects underwent a 6 mm x6 mm macular scan with three OCTA devices in random order,with a 5-minute interval between examinations by different devices.Images of the superficial capillary plexus(SCP)and deep capillary plexus(DCP)were acquired.The following microvascular parameters were compared:foveal superficial capillary plexus vessel density(F-SCP VD),parafoveal superficial capillary plexus vessel density(PF-SCP VD),foveal deep capillary plexus vessel density(F-DCP VD),parafoveal deep capillary plexus vessel density(PF-DCP VD),and the area of the foveal avascular zone(FAZ).
·RESULTS:A total of 34 female patients(68 eyes)treated with HCQ for 5 y due to RA were enrolled in this study,aged 38-58 y with a mean age of 49.3±5.05 y.Statistically significant differences were found in F-SCP VD,PF-SCP VD,F-DCP VD,PF-DCP VD,and FAZ area among measurements obtained by SS-OCTA,SSADA-based FD-OCTA,and OMAG-based FD-OCTA(all P＜0.05).No statistically significant differences in all above parameters were observed between SSADA-based FD-OCTA and OMAG-based FD-OCTA(all P＞0.05).FAZ areas measured by the three devices were highly positively correlated(|r|≥0.8,P＜0.01).The F-SCP VD,PF-SCP VD,F-DCP VD,and PF-DCP VD values obtained by SSADA-based FD-OCTA and OMAG-based FD-OCTA were all highly positively correlated(|r|≥0.8,P＜0.01).The PF-SCP VD and PF-DCP VD values measured by SS-OCTA versus SSADA-based FD-OCTA and OMAG-based FD-OCTA showed moderate positive correlations(0.5≤|r|＜0.8,P＜0.01).The F-SCP VD and F-DCP VD values measured by SS-OCTA versus SSADA-based FD-OCTA and OMAG-based FD-OCTA exhibited low positive correlations(0.3 ≤|r|＜0.5,P＜0.05).Bland-Altman plots demonstrated good agreement between SSADA-based FD-OCTA and OMAG-based FD-OCTA for the measurements of F-SCP VD,PF-SCP VD,F-DCP VD and PF-DCP VD.By contrast,poor agreement was observed when comparing SS-OCTA with SSADA-based FD-OCTA or OMAG-based FD-OCTA for measurements of F-SCP VD,PF-SCP VD,F-DCP VD and PF-DCP VD.Satisfactory agreement was found among the three OCTA devices for FAZ area measurements.
·CONCLUSION:SSADA-based FD-OCTA and OMAG-based FD-OCTA show favorable correlation and agreement in measuring macular vessel density of patients receiving HCQ,which allows cautious interchangeable use during clinical follow-up.The vessel density parameters measured by SS-OCTA were markedly different from those obtained by SSADA-based FD-OCTA and OMAG-based FD-OCTA;therefore,these devices cannot be directly interchanged.FAZ area measurements exhibit favorable inter-device agreement among the three systems,and interchangeability should be considered in the context of clinical practice.关键词
光学相干断层扫描血管成像(OCTA)/羟氯喹/黄斑中心凹/视网膜/血流信号Key words
optical coherence tomography angiography(OCTA)/hydroxychloroquine/fovea/retina/blood flow signal
