农药科学与管理2026，Vol.47Issue(8)：26-33,8.
新型杀虫剂氟啶虫胺腈优化合成工艺研究
Study on the Optimized Synthesis of the Novel Insecticide Sulfoxaflor
王玉竹 1郭中献 2柴梦琰 3尹维平 3郭胜强 3牛草原 3郑先福3
作者信息
- 1. 郑州大学化学学院,河南 郑州 450002
- 2. 开封博凯生物化工有限公司,河南 开封 475000
- 3. 河南农业大学理学院,河南 郑州 450002
- 折叠
摘要
Abstract
Sulfoxaflor is a novel insecticide.To further reduce production costs,enhance productivity,and improve its suitability for industrial-scale production,its synthetic route was optimized.4-Ethoxy-1,1,1-trifluoro-3-buten-2-one was prepared using trifluoroacetyl chloride and vinyl ether as raw materials under the catalysis of pyridine.3-methylsulfanylbutanal was reacted with pyrrolidine to obtain 1-pyrrolidine-3-(methylthio)but-1-en-1-yl.4-Ethoxy-1,1,1-trifluoro-3-buten-2-one and 1-pyrrolidine-3-(methylthio)but-1-en-1-yl underwent cyclization,cyanamination,and oxidation with potassium permanganate to yield the target compound,sulfoxaflor.The overall yield reached 23.2%(based on 3-methylsulfanylbutanal).The newly designed synthetic route improved the yield and is more suitable for industrial production.关键词
氟啶虫胺腈/杀虫剂/合成Key words
sulfoxaflor/insecticide/synthesis分类
农业科技引用本文复制引用
王玉竹,郭中献,柴梦琰,尹维平,郭胜强,牛草原,郑先福..新型杀虫剂氟啶虫胺腈优化合成工艺研究[J].农药科学与管理,2026,47(8):26-33,8.
