生物技术通报2026，Vol.42Issue(8)：47-59,13.DOI:10.13560/j.cnki.biotech.bull.1985.2025-1208
遗传多效性及其在畜禽重要经济性状遗传解析中的研究进展
Genetic Pleiotropy and Its Research Progress in the Genetic Dissection of Key Economic Traits in Livestock and Poultry
摘要
Abstract
Genetic pleiotropy refers to the biological phenomenon in which a single gene or genetic variation simultaneously influences multiple phenotypic traits or diseases.With the rapid development of omics technology,pleiotropy research has achieved significant advances in revealing the genetic basis and molecular mechanisms of human complex traits and diseases,and a large number of pleiotropic genes and functional genetic variant sites have been identified.Important economical traits in livestock and poultry are predominantly complex in nature and commonly exhibit both phenotypic and genetic correlations,and genetic pleiotropy is one of the important mechanisms underlying this phenomenon.However,current studies on pleiotropy related to important economic traits in livestock and poultry remain relatively limited,primarily due to constraints in research strategies and technical approaches.By adapting successful methodologies from studies of human complex traits and diseases and applying them to livestock and poultry,it is conducive to deeply understanding the shared genetic architecture among correlated traits,clarifying the nature of these correlations(synergistic or antagonistic),thereby ultimately providing a robust theoretical basis for designing scientifically sound,rational,and efficient breeding programs.This review systematically summarizes the historical development,molecular mechanisms,commonly used study methods of genetic pleiotropy,and advances in the analysis of pleiotropy in important economic traits of livestock and poultry.It aims to provide references for further elucidation of the genetic basis of these traits,facilitating the discovery of pleiotropic genes and related molecular markers,and promoting genetic improvement in livestock and poultry.关键词
畜禽/重要经济性状/遗传基础/多效性Key words
livestock and poultry/important economic traits/genetic basis/pleiotropy引用本文复制引用
韩亚倩,李辉,王守志..遗传多效性及其在畜禽重要经济性状遗传解析中的研究进展[J].生物技术通报,2026,42(8):47-59,13.基金项目
国家自然科学基金项目(32372867),国家农业科技重大项目(NK20221001),国家现代农业产业技术体系(CARS-41) （32372867）
