生殖医学杂志2026，Vol.35Issue(8)：959-964,6.DOI:10.3969/j.issn.1004-3845.2026.08.001
降调节后激素替代周期方案联合宫腔灌注HCG对反复种植失败患者妊娠结局的影响
Effect of hormone replacement protocol after down-regulation combined with intrauterine perfusion of HCG on pregnancy outcomes in patients with recurrent implantation failure
摘要
Abstract
Objectives:To investigate the efficacy of hormone replacement protocol after down-regulation combined with intrauterine perfusion of human chorionic gonadotropin(HCG)in patients with recurrent implantation failure(RIF). Methods:A retrospective analysis was conducted on the clinical data of 90 RIF patients who underwent frozen-thawed blastocyst transfer in the Reproductive Medicine Center of Affiliated Maternal &Child Health Hospital of Nantong University from January 2024 to June 2025.According to the treatment regimens,the patients were divided into the control group(endometrial preparation with hormone replacement cycle after down-regulation,n=45)and the study group(same endometrial preparation as in the control group,with additional intrauterine HCG perfusion before embryo transfer,n=45).Uterine artery hemodynamic parameters[peak systolic velocity(PSV),end-diastolic velocity(EDV)and resistance index(RI),endometrial blood flow patterns],serum levels of inflammatory factors[interleukin(IL)-6,IL-10,interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α)]and pregnancy outcomes were compared between the two groups. Results:There was no significant difference in the general baseline characteristics between the two groups(P＞0.05).After embryo transfer,the PSV,EDV,and RI in the study group were significantly lower than those in the control group(P＜0.05).The proportion of type Ⅱ+type Ⅲendometrial blood flow was significantly higher in the study group than that in the control group(P＜0.05).The serum levels of IL-6,TNF-α were significantly lower,while IL-10 significantly higher in the study group than those in the control group(P＜0.05).No significant difference was found in early miscarriage rate between the two groups(P＞0.05).Compared with that in the control group,the biochemical pregnancy rate in the study group was significantly lower(11.11％vs.28.89％,P＜0.05),while the blastocyst implantation rate(40.00％vs.24.44％)and clinical pregnancy rate(75.56％vs.46.67％)in the study group were significantly higher(P＜0.05). Conclusions:Hormone replacement protocol after down-regulation combined with intrauterine HCG perfusion can improve uterine artery blood flow,optimize endometrial blood flow patterns,regulate the inflammatory factor levels,and ultimately improve pregnancy outcomes in RIF patients.关键词
降调节/激素替代周期/宫腔灌注/人绒毛膜促性腺激素/反复种植失败Key words
Downregulation/Hormone replacement protocol/Intrauterine infusion/Human chorionic gonadotropin/Recurrent implantation failure分类
医药卫生引用本文复制引用
朱洁,朱怡,沈亚..降调节后激素替代周期方案联合宫腔灌注HCG对反复种植失败患者妊娠结局的影响[J].生殖医学杂志,2026,35(8):959-964,6.基金项目
江苏省自然科学基金(BK20221417) （BK20221417）
南通市卫生健康委员会科研课题(QN2024045) （QN2024045）
