实用中医内科杂志2026，Vol.40Issue(8)：121-125,后插1,6.DOI:10.13729/j.issn.1671-7813.Z25082606
基于脑肠轴探讨色氨酸-犬尿氨酸代谢在焦虑障碍中的作用及与肝脾同调的相关性
To Explore the Role of Tryptophan-Kynurenine Metabolism in Anxiety Disorder and it's Correlation with Liver-spleen Coherence Based on Brain-gut Axis
摘要
Abstract
Anxiety disorder is a common mental disease characterized by excessive worry and somatic symptoms.Its pathogenesis is complex,the global incidence is increasing year by year,and the cure rate is low.In recent years,the rise of brain-gut axis theory provides a new perspective for its research.Tryptophan-kynurenine metabolic pathway is a key link in the regulation of brain-gut axis,and its imbalance is related to neurotransmitter disorder,inflammatory response and intestinal flora imbalance,which affects the occurrence and development of anxiety disorder through multiple ways.Traditional Chinese medicine believes that the loss of liver and spleen is the basic pathogenesis of anxiety disorder.Mod-ern studies have found that the imbalance of liver and spleen can activate the hypothalamic-pituitary-adrenal axis and regulate the intestinal flora,which coincide with the pathogenesis of anxiety disorder under the theory of brain-gut axis.This article systematically elaborates the mechanism of tryptophan-kynurenine metabolic pathway under the regulation of brain-gut axis in anxiety disorder,and its correlation with the theory of liver-spleen coherence in traditional Chinese med-icine,in order to provide new ideas for the intervention of anxiety disorder.关键词
焦虑障碍/脑肠轴/色氨酸-犬尿氨酸/肝脾同调Key words
anxiety disorder/gut-brain axis/yryptophan-kynurenine/liver and spleen are in tune分类
医药卫生引用本文复制引用
杨娅妮,彭晓明,马鹏程,曹艳春,张润..基于脑肠轴探讨色氨酸-犬尿氨酸代谢在焦虑障碍中的作用及与肝脾同调的相关性[J].实用中医内科杂志,2026,40(8):121-125,后插1,6.基金项目
甘肃省自然科学基金项目(24JRRA1039) （24JRRA1039）
兰州市科技局计划项目(2024-4-6) （2024-4-6）
