生殖医学杂志2026，Vol.35Issue(8)：1014-1019,6.DOI:10.3969/j.issn.1004-3845.2026.08.008
新疆地区育龄期女性年龄特异性血清抗苗勒管激素参考区间的建立及临床评估体系的构建:一项基于37 886例的横断面研究
Establishment of age-specific serum anti-Müllerian hormone reference intervals and construction of a clinical assessment system for women of reproductive age in Xinjiang:a cross-sectional study based on 37 886 cases
摘要
Abstract
Objectives:To establish age-specific reference intervals for serum anti-Müllerian hormone(AMH)in a large sample of women of reproductive age in Xinjiang,construct a five-tier grading evaluation system directly applicable for clinical decision-making,and identify abnormal subgroups with clear clinical significance based on this system. Methods:Clinical data were retrospectively collected from women aged 20-45 years old who underwent AMH testing at the People's Hospital of Xinjiang Uygur Autonomous Region between January 2021 and December 2025.Following strict clinical exclusion criteria,37 886 women of reproductive age were included.The non-parametric percentile method was used to calculate the percentiles(P2.5,P25,P50,P75,and P97.5)of AMH levels for each single-year age group.Age-specific reference intervals were established based on Loess smoothing curves.A five-tier clinical grading system was constructed via age-correction,and subgroups with abnormal AMH levels were further identified. Results:The mean age of the study population was(34.01±6.20)years old.After age correction,the median AMH peaked at 21 years old(5.29 ng/ml)and remained at a high level during 20-24 years old,and then declined with age advancing,with an accelerated decline after 35 years old.Detailed reference intervals for 26 single-age points and an age-corrected five-tier clinical grading quick-reference table were established.Based on the single-age reference intervals,two abnormal subgroups were identified:a young low-AMH subgroup(＜35 years old and AMH＜P2.5)comprising 487 cases(2.4％of peers),with a median AMH of 0.05 ng/ml;and an elderly high-AMH subgroup(≥35 years old and AMH＞P97.5)comprising 431 cases(2.4％of peers),with a median AMH of 6.97 ng/ml. Conclusions:This study establishes large-sample,age-specific AMH reference intervals and a five-tier clinical grading system for women in Xinjiang for the first time.It successfully identifies two abnormal subgroups with clear clinical significance.The findings provide a scientific and practical tool for the rapid assessment of ovarian reserve function and early identification of abnormal status among local women.关键词
抗苗勒管激素/参考区间/临床分级/异常亚群/卵巢储备/新疆地区Key words
Anti-Müllerian hormone/Reference interval/Clinical grading/Abnormal subgroup/Ovarian reserve/Xinjiang region分类
医药卫生引用本文复制引用
马洁,郭敏,王文玲,张彩荣,隋霜,韩翠柳,朱开春..新疆地区育龄期女性年龄特异性血清抗苗勒管激素参考区间的建立及临床评估体系的构建:一项基于37 886例的横断面研究[J].生殖医学杂志,2026,35(8):1014-1019,6.基金项目
新疆维吾尔自治区卫生健康委员会委托项目"天山英才"医药卫生高层次人才培养计划(TSYC202301B050) （TSYC202301B050）
