生殖医学杂志2026，Vol.35Issue(8)：1074-1079,6.DOI:10.3969/j.issn.1004-3845.2026.08.017
驱动蛋白KIF18B在肿瘤与女性生殖中的研究进展
Advances in the role of KIF18B motor protein in cancer and female reproductive biology
摘要
Abstract
Kinesin family member 18B(KIF18B)is a crucial regulator of microtubule dynamics and chromosome segregation.It ensures accurate chromosome alignment during mitosis and plays an essential role in maintaining genomic integrity.In recent years,KIF18B has attracted extensive attention in the research of tumorigenesis and female fertility preservation.In tumors,KIF18B overexpression drives tumorigenesis and progression by inducing chromosomal instability and regulating key signaling pathways.In the field of reproductive health,aberrant KIF18B function is closely linked to declined oocyte quality,diminished ovarian reserve and decreased endometrial receptivity,which directly impairs female fertility.This review comprehensively outlines the molecular regulatory mechanisms of KIF18B,focusing on its roles in cancer and female reproductive function,and related translational research progress,and further discusses its potential as a bridging node between oncology and reproductive medicine,as well as future research perspectives.关键词
KIF18B/细胞分裂/肿瘤/生育力保存Key words
KIF18B/Cell division/Tumor/Fertility preservation分类
医药卫生引用本文复制引用
王薇,戴柏,托娅,戴晓怡..驱动蛋白KIF18B在肿瘤与女性生殖中的研究进展[J].生殖医学杂志,2026,35(8):1074-1079,6.基金项目
内蒙古自治区重点研发和成果转化计划项目(2023YFSH0011) （2023YFSH0011）
