特产研究2026，Vol.48Issue(4)：51-58,64,9.DOI:10.16720/j.cnki.tcyj.2026.135
基于AHP-熵权法结合Box-Behnken响应面法的金银花蒲公英丹参颗粒成型工艺优化研究
Optimization of Honeysuckle,Dandelion,and Danshen Granule Forming Process Based on AHP Entropy Weight Method Combined with Box-Behn-ken Response Surface Methodology
摘要
Abstract
To optimize the molding process of honeysuckle,dandelion,and Danshen granules.Based on single factor experiments in this study,Plackett Burman design to screen key parameters;using the molding rate,moisture absorption rate,and angle of repose as indicators,the combination weight were determined by the AHP entropy weight method,and the process was optimized and verified using the Box Be-hnken response surface method.Diluent was determined as the optimal dextrin,and the key parameters were the ratio of dextrin to dry extract powder,ethanol concentration,and ethanol dosage.The combined weights of the three are 0.472,0.346,and 0.182,respectively.The optimal process is:dextrin dry paste powder ratio of 1.07∶1,ethanol concentration of 94％,ethanol dosage of 40.7％,PVP-K30 concentration of 3％,and drying at 50℃ for 420 minutes.The average comprehensive score of the verification experiment was 99.20,with RSD＜2％.This pro-cess is stable and feasible,and can provide a basis for industrial production.关键词
金银花/蒲公英/丹参/颗粒剂/AHP-熵权法/响应面设计/成型工艺Key words
Lonicerae japonicae/Taraxacum mongolicum/Salviae miltiorrhizae/granules/AHP-entropy weight method/response surface methodology/molding process分类
医药卫生引用本文复制引用
戴莎莎,苏怀雨,孙健伟,陈琳,吕姝寰,吕欣澳,李海燕..基于AHP-熵权法结合Box-Behnken响应面法的金银花蒲公英丹参颗粒成型工艺优化研究[J].特产研究,2026,48(4):51-58,64,9.基金项目
吉林省科技厅科技发展计划项目(20260301030YY) （20260301030YY）
