空军军医大学学报2026，Vol.47Issue(8)：1093-1099,7.DOI:10.13276/j.issn.2097-1656.2026.08.001
支气管胸膜瘘诊疗:从传统手术到生物精准修复的范式转变与未来展望
Bronchopleural fistula management:paradigm shift from conventional surgery to biologically oriented precision repair and future perspectives
摘要
Abstract
Bronchopleural fistula(BPF)is defined as an abnormal pathological communication between the bronchial tree and the pleural cavity,allowing the passage of air,secretions,or infectious materials.It represents a severe complication following thoracic surgery and can also result from infection,trauma,tumors,or iatrogenic injuries.Although the incidence of BPF remains low,its high mortality,challenging management,and prolonged clinical course have long made it a persistent clinical dilemma in the fields of thoracic surgery and interventional pulmonology.In recent years,with the rapid advancement of respiratory endoscopy,biomaterials,regenerative medicine,and precision surgery,the diagnostic and therapeutic paradigm for BPF has shifted from traditional open surgery toward minimally invasive interventions,biological repair,and individualized precision treatment.This article systematically reviews the etiology,pathogenesis,clinical manifestations,diagnostic approaches,conventional treatments,and prognosis of BPF.Based on the latest domestic and international research developments,the clinical application of innovative modalities including endoscopic closure,novel biomaterials,tissue-engineered repair,robotic-assisted surgery,and minimally invasive techniques is highlighted.Furthermore,existing challenges and future directions are discussed,aiming to provide a theoretical foundation for optimizing clinical management and guiding related research endeavors.关键词
支气管胸膜瘘/呼吸内镜/内镜封堵/微创介入/生物材料/再生医学/富血小板血浆/脓胸Key words
bronchopleural fistula/respiratory endoscopy/endoscopic closure/minimally invasive intervention/biomaterials/regenerative medicine/platelet-rich plasma/empyema分类
医药卫生引用本文复制引用
金发光..支气管胸膜瘘诊疗:从传统手术到生物精准修复的范式转变与未来展望[J].空军军医大学学报,2026,47(8):1093-1099,7.基金项目
国家自然科学基金面上项目(82270084) （82270084）
空军军医大学交叉融合专项(2023JC008) （2023JC008）
