诊断学理论与实践2026，Vol.25Issue(4)：399-405,7.DOI:10.16150/j.1671-2870.2026.04.002
非小细胞肺癌的气道播散临床意义及研究进展
Clinical significance and research progress of spread through air spaces(STAS)in non-small cell lung cancer
钟华 1黄莉棠 1杜华薇1
作者信息
- 1. 上海交通大学医学院附属胸科医院呼吸与危重症医学科,上海 200030
- 折叠
摘要
Abstract
Spread through air spaces(STAS),defined as the presence of tumor cells within the air spaces of the lung parenchyma beyond the edge of the main tumor,represents a novel pattern of invasion in lung cancer.Since its formal defi-nition by the World Health Organization in 2015,STAS has fundamentally reshaped the risk stratification and treatment paradigms for non-small cell lung cancer(NSCLC).With the publication of data from the large-scale JCOG0802/WJOG4607L clinical trials conducted by the Japan Clinical Oncology Group and the West Japan Oncology Group,STAS has evolved from a mere pathological feature into an independent risk factor affecting recurrence-free survival(RFS)and overall survival(OS)in early-stage NSCLC,emerging as a pivotal biomarker for determining the surgical approach(lobec-tomy or sublobar resection)and postoperative adjuvant therapy decisions.This review systematically outlines the definition,diagnosis,and preoperative multimodal imaging prediction models of STAS.Furthermore,it elucidates the selection of sur-gical resection extent based on STAS status and presents the latest evidence-based data regarding adjuvant therapy,aiming to provide practical guidance for clinicians in standardizing diagnosis and treatment.关键词
非小细胞肺癌/气道播散/肺叶切除术/辅助化疗Key words
Non-small cell lung cancer/Spread through air spaces/Sublobar resection/Adjuvant chemotherapy分类
医药卫生引用本文复制引用
钟华,黄莉棠,杜华薇..非小细胞肺癌的气道播散临床意义及研究进展[J].诊断学理论与实践,2026,25(4):399-405,7.
