中国病理生理杂志2026，Vol.42Issue(8)：1660-1666,7.DOI:10.3969/j.issn.1000-4718.2026.08.020
内皮-间充质转化在心脏毒性中作用机制及干预策略的研究进展
Progress in mechanisms and intervention strategies of endothelial-mesen-chymal transition in cardiotoxicity
摘要
Abstract
Endothelial-mesenchymal transition(EndMT)is a process in which endothelial cells lose their en-dothelial characteristics and acquire mesenchymal features in response to external stimuli.While EndMT is essential for physiological cardiac development,aberrant EndMT is widely involved in the onset and progression of cardiovascular dis-eases.Cardiotoxicity refers to heart damage caused by toxic agents such as drugs,radiation,or viruses,and may result in serious cardiovascular conditions,including heart failure,cardiac fibrosis,and valvular heart disease.A growing body of research has demonstrated that EndMT plays a crucial regulatory role in the development of cardiotoxicity.This review summarizes the effects and molecular mechanisms by which exogenous toxic substances induce EndMT to cause cardio-toxicity.It also discusses therapeutic strategies targeting EndMT to alleviate cardiotoxicity and outlines future directions for research in this area,aiming to provide reference materials for the clinical management of cardiotoxicity.关键词
心脏毒性/内皮-间充质转化/分子机制/治疗策略Key words
cardiotoxicity/endothelial-mesenchymal transition/molecular mechanism/therapeutic strategy分类
医药卫生引用本文复制引用
朱林,高红刚,赵立敏,秦玮..内皮-间充质转化在心脏毒性中作用机制及干预策略的研究进展[J].中国病理生理杂志,2026,42(8):1660-1666,7.基金项目
中国博士后科学基金资助项目(No.2024M761149) （No.2024M761149）
山东省自然科学基金联合基金资助项目(No.ZR2024LMB019) （No.ZR2024LMB019）
山东省博士后创新项目(No.SDCX-ZG-202502106) （No.SDCX-ZG-202502106）
济宁医学院院士工作站科研基金(No.JYHL2025KY06) （No.JYHL2025KY06）
