心理科学进展2026，Vol.34Issue(9)：1500-1513,14.DOI:10.3724/SP.J.1042.2026.1500
网络连接靶向的近红外神经反馈对工作记忆重度衰退的干预效果与机制
The effects and mechanisms of connectome-targeted fNIRS neurofeedback intervention for severe working memory decline
摘要
Abstract
Systemic deviation of large-scale brain network coordination patterns is the core neural mechanism of working memory aging,and the severe decline in working memory significantly impairs older individuals'quality of life while imposing heavy burdens on society.Existing neuromodulation techniques are either limited to single-point interventions or simplify network feedback signals,making it difficult to reflect the holistic profile of multi-node dynamic coordination.Furthermore,constrained by factors such as equipment safety and portability,current methods fail to meet the long-term intervention needs of the elderly.This study aims to construct a connectome-targeted fNIRS neurofeedback intervention framework:First,multivariate pattern analysis(MVPA)is employed to identify specific network connectivity patterns that significantly distinguish severely-declined groups from function-maintained groups for network target setting.Second,using the spatial similarity between an individual's real-time network connectivity pattern(retaining topological properties)and the target pattern as the feedback index,a closed-loop neurofeedback system is constructed to guide autonomous modulation and systematically evaluate its intervention efficacy.Finally,the performance characteristics of cognitive transfer effects are comprehensively examined across multiple dimensions,and the potential dual-pathway transfer mechanism—comprising"network direct-driven"and"working memory-mediated"pathways—is verified through mediation analysis.This research is expected to provide a novel intervention scheme for improving severe working memory decline and offer a theoretical framework and methodological reference for network-targeted modulation strategies.关键词
工作记忆老化/网络连接调控/近红外神经反馈/认知迁移/双路径机制Key words
working memory aging/network connectivity modulation/fNIRS neurofeedback/cognitive transfer/dual-pathway mechanism分类
社会科学引用本文复制引用
侯鑫..网络连接靶向的近红外神经反馈对工作记忆重度衰退的干预效果与机制[J].心理科学进展,2026,34(9):1500-1513,14.基金项目
国家自然科学基金青年科学基金项目(C类)(32500985) （C类）
教育部人文社会科学青年基金研究项目(24YJCZH092)资助. （24YJCZH092）
