中国比较医学杂志2026，Vol.36Issue(15)：118-127,10.DOI:10.3969/j.issn.1671-7856.2026.15.012
水凝胶支架修复骨质疏松骨缺损的机制及研究进展
The mechanisms and advances in hydrogel scaffold repair of osteoporotic bone defects
摘要
Abstract
Osteoporosis(OP)is a systemic metabolic disease characterized by disrupted bone homeostasis.Bone defects caused by OP are difficult to repair owing to an imbalanced bone microenvironment.Traditional therapies have limited efficacy,numerous complications,and complex treatment procedures.Hydrogel scaffolds have emerged as novel repair materials owing to their excellent biocompatibility and unique network structure,which can repair osteoporotic bone defects by promoting angiogenesis and regulating immune responses.This review systematically summarizes the development status and therapeutic mechanisms of hydrogel scaffolds in repairing osteoporotic bone defects,and discusses their application prospects and limitations.Multi-material hydrogel systems can facilitate the osteoporotic bone defect repair through intelligent environmental responses and diverse bioactive molecules or cell delivery,representing an ideal therapeutic strategy.Future research may focus on advancing the functional modification and clinical translation of hydrogels,and provide new directions and insights for basic research and clinical treatment of osteoporotic bone defects through in-depth investigations into their mechanisms of action.关键词
骨质疏松/骨缺损/水凝胶/组织工程/骨修复/生物材料Key words
osteoporosis/bone defect/hydrogel/tissue engineering/bone repair/biological material分类
医药卫生引用本文复制引用
黄筱涵,刘钰林,李秀茹,陆真慧,江献芳,郑立..水凝胶支架修复骨质疏松骨缺损的机制及研究进展[J].中国比较医学杂志,2026,36(15):118-127,10.基金项目
国家自然科学基金(52573316,82160188) （52573316,82160188）
广西医科大学一流学科创新驱动人才计划(江献芳). （江献芳）
