中国比较医学杂志2026，Vol.36Issue(15)：128-139,12.DOI:10.3969/j.issn.1671-7856.2026.15.013
DNA甲基化与m6A修饰在失眠中的协同调控作用与机制
DNA methylation and m6A RNA modification:synergistic regulatory roles and underlying mechanisms in insomnia
摘要
Abstract
Insomnia is a sleep disorder with a high global incidence;its pathogenesis is complex,involving the interaction of genetic predisposition,environmental stress,and psychophysiological factors.Epigenetics is a molecular mechanism that affects gene expression through environmental interaction.DNA methylation and N6-methyladenosine(m6A)modification are epigenetic mechanisms triggered by environmental stress and other factors,resulting in lasting changes in gene expression;they are a molecular bridge connecting external triggers and intrinsic susceptibility to insomnia.This article aims to systematically consolidate the existing evidence on the association between DNA methylation and m6A modification and insomnia,explore the core mechanism of insomnia affecting the regulation of circadian rhythm and the expression of neurologically related genes,confirm specific epigenetic profile changes in patients with insomnia,and propose future research directions to promote the discovery of biomarkers and the translation of epigenetic therapies through multi-omics integration and longitudinal research.关键词
失眠/DNA甲基化/m6A修饰/表观遗传学Key words
insomnia/DNA methylation/m6A modification/epigenetics分类
医药卫生引用本文复制引用
周艳丽,陈瑶,刘京霞,高希言,郭娅静..DNA甲基化与m6A修饰在失眠中的协同调控作用与机制[J].中国比较医学杂志,2026,36(15):128-139,12.基金项目
国家自然科学基金(82474655,82405585) （82474655,82405585）
河南省重点研发专项(251111311400) （251111311400）
河南省科技攻关项目(252102311264) （252102311264）
中国博士后科学基金(2025M773941). （2025M773941）
