中国动物传染病学报2026，Vol.34Issue(3)：155-167,13.
5株H9N2亚型禽流感病毒的遗传进化分析
Genetic Evolution Analysis of Five H9N2 Subtype Avian Influenza Viruses
摘要
Abstract
This study employed whole-genome sequencing and molecular characterization and phylogenetic tree analysis to investigate the genetic evolution of five H9N2 subtype Avian influenza viruses(AIVs)that were isolated from Guangdong.In this study,the amino acid sequences of the cleavage site in their HA protein included RASR↓GLF and RSSR↓GLF,only having a single basic amino acid,which was a molecular characteristic of the low-pathogenic AIV.Except for the S183 strain,the other four viruses possessed L at 234 site(encoded as H9)in their HA protein,indicating a preference for binding to α-2,6-sialic acid receptors.All of these H9N2 AIVs had G at 236 site in their HA protein.All five viruses showed E and D at the 627 and 701 sites of the PB2 protein,which were typical molecular characteristics of AIV from birds.Genetic evolution analysis indicated that the HA and NA genes of these five H9N2 Avian influenza virus strains belonged to the Y280-like lineage,the PB2 and M genes belonged to the G1-like lineage,and the PB1,PA and NP genes belonged to the F/98-like lineage.In conclusion,this study provided scientific data for understanding the genetic evolution and epidemiological characteristics of H9N2 AIV.关键词
H9N2亚型/禽流感病毒/分子特征/遗传进化Key words
H9N2 subtype/Avian influenza virus/molecular characteristics/genetic evolution分类
农业科技引用本文复制引用
宋苏美,焦培荣,关蕴,卢军,黄小武,张俊生,赵璐翔,袁世超,王英英,杨素..5株H9N2亚型禽流感病毒的遗传进化分析[J].中国动物传染病学报,2026,34(3):155-167,13.基金项目
国家重点研发计划项目(2021YFD1800202) （2021YFD1800202）
国家自然科学基金项目(32072844) （32072844）
岭南现代农业科学与技术广东省实验室重大专项项目(NT2021007) （NT2021007）
