中国医学装备2026，Vol.23Issue(8)：40-45,6.DOI:10.3969/j.issn.1672-8270.2026.08.008
动态增强MRI与DWI联合应用在肝细胞癌Ki-67表达水平的价值研究
Combined prediction of DCE-MRI and DWI for Ki-67 expression level in HCC
摘要
Abstract
Objective:To investigate value of combined prediction of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and diffusion-weighted imaging(DWI)for Ki-67 expression level in hepatocellular carcinoma(HCC),so as to provide basis for noninvasive assessing proliferative activity of tumor in clinical practice.Methods:A total of 150 HCC patients admitted to the Second Affiliated Hospital of Anhui Medical University between January 2020 and January 2025 were enrolled in this study.Based on Ki-67 expression level of postoperative pathological cell proliferation marker,the patients were divided into a high-expression group(n=90)and a low-expression group(n=60).All participants underwent preoperative DCE-MRI and DWI examinations.Imaging parameters,including the volume transfer constant(Ktrans),rate constant(Kep),extravascular extracellular volume fraction(Ve),and apparent diffusion coefficient(ADC),were measured.Results:In the comparison of imaging parameters,the difference of Ve was not significant between high-expression group and low-expression group(P>0.05),and the Ktrans and Kep of high-expression group were respectively(0.35±0.12)min-1 and(1.23±0.45)min-1,all of which were higher than(0.28±0.09)min-1 and(0.98±0.38)min-1 of low-expression group,and the differences were significant(t=3.456,2.987,P<0.05).The ADC value of high-expression group was(950.45±120.67)×10-6 mm2/s,which was lower than(1 050.78±135.89)×10-6 mm2/s of low-expression group,and the difference was significant(t=-3.210,P<0.05).The maximum diameter of tumor,and serum AFP level of high-expression group were all higher than those of low-expression group,and the differences of them were significant(t=4.567,7.890,P<0.05).The difference of the grading of hepatic function between two groups was significant(x2=5.432,P<0.05).The results of multivariate logistic regression analysis indicated that Ktrans,ADC and AFP were independent predictors for Ki-67 high expression(OR=1.412,0.996,1.002,P<0.05).Receiver operating characteristic(ROC)curve analysis indicated that the diagnostic performance of combined prediction model was highest in distinguishing expression statuses of Ki-67.Conclusion:The combined application of DCE-MRI and DWI can effectively predict expression level of Ki-67 in HCC.The combination of imaging parameters and clinical indicators can significantly improve predictive accuracy,which has higher potential in clinical application.关键词
动态增强磁共振成像(DCE-MRI)/弥散加权成像(DWI)/肝细胞癌/细胞增殖核抗原(Ki-67)Key words
Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)/Diffusion-weighted imaging(DWI)/Hepatocellular carcinoma(HCC)/Proliferation marker Ki-67(Ki-67)分类
医药卫生引用本文复制引用
濮毅峰,谢伟选,许怀生,张彬..动态增强MRI与DWI联合应用在肝细胞癌Ki-67表达水平的价值研究[J].中国医学装备,2026,23(8):40-45,6.基金项目
国家自然科学基金(82370591)National Natural Science Foundation of China(82370591) （82370591）
