中国药房2026，Vol.37Issue(16)：2161-2165,5.DOI:10.6039/j.issn.1001-0408.2026.16.14
氟替美维吸入粉雾剂与布地格福吸入气雾剂治疗稳定期哮喘-慢阻肺重叠综合征的疗效与安全性比较
Comparison of the efficacy and safety of Fluticasone furoate/umeclidinium/vilanterol and Budesonide/glycopyrronium/formoterol in the treatment of stable asthma-COPD overlap syndrome
摘要
Abstract
OBJECTIVE To compare the clinical efficacy and safety of Fluticasone furoate/umeclidinium/vilanterol(FF/UMEC/VI)and Budesonide/glycopyrronium/formoterol(BUD/GLY/FOR)in the treatment of stable asthma-chronic obstructive pulmoary disease(COPD)overlap syndrome(ACOS).METHODS A retrospective analysis was performed on clinical data of 157 patients with stable ACOS who received standardized treatment at the Affiliated Hospital of Xuzhou Medical University from March 2023 to March 2025.Patients were assigned to the FF/UMEC/VI group(n=80,receiving FF/UMEC/VI in addition to baseline therapy)and the BUD/GLY/FOR group(n=77,receiving BUD/GLY/FOR in addition to baseline therapy)according to the treatment regimens.The lung function parameters[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC,FEV1 percentage of predicted value(FEV1%pred),peak expiratory flow(PEF)],inflammatory markers[peripheral blood eosinophils(EOS)count,fractional exhaled nitric oxide(FeNO)level,serum levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)],and clinical symptom assessment indicators[Asthma Control Test(ACT)scores,COPD Assessment Test(CAT)scores,modified Medical Research Council Dyspnea Scale(mMRC)grades]were compared between the two groups at baseline,week 12 and week 24.The occurrences of acute exacerbations and adverse reactions during the 24-week treatment were documented.RESULTS At baseline,there were no statistically significant differences in lung function parameters,inflammatory markers,or clinical symptom assessment indicators between the two groups(P＞0.05).At weeks 12 and 24,all the above indicators in both groups were significantly improved compared with pre-treatment values in the same group(P＜0.05).The FF/UMEC/VI group showed significantly greater improvements in FEV1,FEV1%pred and PEF at week 24,as well as IL-6 and TNF-α levels,ACT and CAT scores,and mMRC grades at both weeks 12 and 24,than the BUD/GLY/FOR group at the corresponding time points(P＜0.05).Within the 24-week treatment,the incidence and frequency of acute exacerbations in the FF/UMEC/VI group were significantly lower than those in the BUD/GLY/FOR group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).CONCLUSIONS Both FF/UMEC/VI and BUD/GLY/FOR can effectively improve lung function,reduce inflammation,and alleviate symptoms in patients with ACOS,and both demonstrate good safety profiles;FF/UMEC/VI shows more pronounced advantages in improving long-term lung function,reducing levels of systemic inflammatory markers,and preventing and controlling acute exacerbations,making it more suitable for the long-term management of patients with ACOS in the stable phase.关键词
氟替美维吸入粉雾剂/布地格福吸入气雾剂/哮喘-慢阻肺重叠综合征/稳定期/肺功能/炎症Key words
Fluticasone furoate/umeclidinium/vilanterol/Budesonide/glycopyrronium/formoterol/asthma-COPD overlap syndrome/stable phase/lung function/inflammation分类
医药卫生引用本文复制引用
韩露,赵后彤,陈碧,孙理想..氟替美维吸入粉雾剂与布地格福吸入气雾剂治疗稳定期哮喘-慢阻肺重叠综合征的疗效与安全性比较[J].中国药房,2026,37(16):2161-2165,5.基金项目
江苏省自然科学基金项目(No.202404041136) （No.202404041136）
江苏省卫生健康委科研项目(No.H2023005) （No.H2023005）
徐州医科大学附属医院院级科研项目(No.2025ZL28) （No.2025ZL28）
