中成药2026，Vol.48Issue(8)：2612-2617,6.DOI:10.3969/j.issn.1001-1528.2026.08.015
碟花金丝桃xanthones类成分及其抑菌活性研究
Xanthones from Hypericum addingtonii and their antibacterial activity
摘要
Abstract
AIM To study the xanthones from Hypericum addingtonii N.Robson and their antibacterial activity.METHODS The 90％ethanol extract was isolated and purified by silica gel,Sephadex LH-20,ODS and preparative HPLC,then and the structures of the obtained compounds were identified by physicochemical properties and spectral data.The microdilution method was applied to evaluate the antibacterial activity.RESULTS Fifteen xanthones were isolated and identified as hyperxanthone E(1),5-hydroxy-2-methoxyxanthone(2),2-hydroxyxanthone(3),6-O-methyl-2-deprenylrheediaxanthone B(4),toxyloxanthone B(5),1,7-dihydroxyxanthone(6),2-methoxy-3-hydroxyxanthone(7),2,3-dimethoxyxanthone(8),1,5-dihydroxy-6,7-dimethoxyxanthone(9),1,3,5-trihydroxyxanthone(10),1,3,7-trihydroxyxanthone(11),1,7-dihydroxy-3-methoxyxanthone(12),3-methoxy-5'-demethoxycadesin G(13),1,5-dihydroxy-2-methoxyxanthone(14)and 1,7-dihydroxy-6-methoxyxanthone(15).The MIC values of compounds 1-15 against Chromobacterium violaceum ATCC12472 and Pseudomonas aeruginosa were all greater than 500 μg/mL.Among them,at a mass concentration of 250 μg/mL,the inhibition rates of compounds 1,7,10 and 13 on the pigment production of C.violaceum were 88.35％±3.05％,81.61％±2.67％,93.04％±4.20％and 84.51％±3.11％,respectively.CONCLUSION Compounds 1-15 are isolated from H.addingtonii for the first time.Compounds 1,7,10 and 13 exhibit certain inhibitory activity on the pigment production of C.violaceum.关键词
碟花金丝桃/xanthones/分离鉴定/紫色色杆菌/铜绿假单胞菌/群感效应/抑菌活性Key words
Hypericum addingtonii N.Robson/xanthones/isolation and identification/Chromobacterium violaceum/Pseudomonas aeruginosa/quorum sensing/antibacterial activity分类
医药卫生引用本文复制引用
黄洁,黄思齐,滕立平,周忠波..碟花金丝桃xanthones类成分及其抑菌活性研究[J].中成药,2026,48(8):2612-2617,6.基金项目
国家自然科学基金项目(32360110) （32360110）
广西自然科学基金项目(2025GXNSFHA069027) （2025GXNSFHA069027）
