Abstract
Objective To explore the effects of the intensified dosage of rosuvastatin calcium tablets(20 mg/day)compared with the conventional dosage(5 mg/day)on lipid metabolism,arterial endothelial function and inflammatory mediators in elderly patients with coronary atherosclerotic heart disease.Methods A total of 130 elderly patients with coronary heart disease admitted to Jinqiu Hospital in Liaoning Province from May 2024 to October 2025 were selected as the research subjects.They were divided into the control group and the observation group according to the random number table method,with 65 cases in each group.All the enrolled patients received basic symptomatic treatment.The control group was treated with the conventional dose(5 mg/d)of rosuvastatin calcium tablets,while the observation group was treated with the enhanced dose(20 mg/d)of rosuvastatin calcium tablets.The lipid levels[triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],arterial endothelial function[von Willebrand factor(vWF),thrombomodulin(TM),endothelin(ET)],inflammatory mediators[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)],treatment effects,and adverse reactions were compared between the two groups.Results After 4,8,and 12 weeks of treatment,the levels of TG,TC,and LDL-C in both groups decreased,while the level of HDL-C increased.Moreover,the indicators in the observation group were all better than those in the control group,and the differences were statistically significant(P＜0.05).After 4,8,and 12 weeks of treatment,the levels of vWF,TM,and ET in both groups decreased,and the decrease in the observation group was greater than that in the control group,with statistically significant differences(P＜0.05).After 4,8,and 12 weeks of treatment,the levels of hs-CRP,TNF-α,and IL-8 in both groups decreased,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P＜0.05).The effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group(6.15%,4/65)and the control group(4.62%,3/65)(P＞0.05).Conclusion The clinical efficacy of rosuvastatin calcium tablets at a dose of 20 mg/day in the intensive treatment of elderly patients with coronary atherosclerotic heart disease is superior to that of the conventional dose of 5 mg/day.It can effectively regulate lipid metabolism,improve arterial endothelial function,and alleviate inflammatory responses,and no obvious serious adverse reactions were observed.关键词
冠状动脉粥样硬化性心脏病/瑞舒伐他汀钙片/强化治疗/动脉内皮功能/血脂Key words
Coronary atherosclerotic heart disease/Rosuvastatin calcium tablets/Intensified treatment/Arterial endothelial function/Blood lipid分类
医药卫生
