中国药物经济学2026，Vol.21Issue(6)：75-78,4.DOI:10.12010/j.issn.1673-5846.2026.06.014
不同剂量阿司匹林对老年动脉粥样硬化患者炎症介质表达的影响
Effects of Different Doses of Aspirin on the Expression of Inflammatory Mediators in Elderly Patients with Atherosclerosis
韩雪1
作者信息
- 1. 辽宁省健康产业集团阜新矿总医院神经内科,辽宁 阜新 123000
- 折叠
摘要
Abstract
Objective To explore the effects of different doses of aspirin on the expression of inflammatory mediators in elderly patients with atherosclerosis.Methods A total of 120 elderly patients with atherosclerosis who were treated at Fuxin General Hospital of Liaoning Health Industry Group from August 2022 to August 2025 were selected as the research subjects.According to the principle of random envelope drawing,they were divided into the low-dose group and the high-dose group,with 60 cases in each group.The low-dose group was treated with low-dose aspirin enteric-coated tablets,while the high-dose group was treated with high-dose aspirin enteric-coated tablets.The therapeutic effects of the two groups were compared.Results After 12 weeks of treatment,the levels of serum interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)in both groups were lower than those before treatment(P＜0.05),but there was no statistically significant difference between the groups(P＞0.05).There was no statistically significant difference in the treatment efficacy between the two groups(P＞0.05).After 12 weeks of treatment,the Barthel scores of both groups were higher than those before treatment(P＜0.05),but there was no statistically significant difference between the groups(P＞0.05).The incidence of adverse reactions in the low-dose group was significantly lower than that in the high-dose group(P＜0.05).Conclusion Compared with high doses,the application of low-dose aspirin in elderly patients with atherosclerosis can also inhibit the expression of inflammatory mediators,improve daily living ability and increase efficiency,and reduce the adverse reactions.关键词
剂量/阿司匹林/动脉粥样硬化/炎症介质Key words
Dosage/Aspirin/Atherosclerosis/Inflammatory mediators分类
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韩雪..不同剂量阿司匹林对老年动脉粥样硬化患者炎症介质表达的影响[J].中国药物经济学,2026,21(6):75-78,4.
